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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2007 Volume 30 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2007 Volume 30 Issue 3

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Article

In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells

  • Authors:
    • María Luisa Hernández-Bule
    • María Ángeles Trillo
    • María Antonia Cid
    • Jocelyne Leal
    • Alejandro Úbeda

  • View Affiliations / Copyright

    Affiliations: Dep. Investigación - BEM, Hospital Ramón y Cajal, 28034 Madrid, Spain
  • Pages: 583-592
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/ijo.30.3.583
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Abstract

Capacitive-resistive electric transfer (CRET) therapy is a non-invasive technique currently applied to the treatment of skin, muscle and tendon injuries that uses 0.45-0.6 MHz electric currents to transdermically and focally increase the internal temperature of targeted tissues. Because CRET electrothermal treatment has been reported to be more effective than other thermal therapies, it has been proposed that the electric stimulus could induce responses in exposed tissues that are cooperative or synergic with the thermal effects of the treatment. Previous studies by our group, investigating the nature of the alleged electric response, have shown that short, repeated stimuli with 0.57-MHz currents at subthermal levels could provoke partial, cytotoxic effects on human neuroblastoma cells in vitro. The aim of the present study was to investigate the response from another human cell type, the human hepatocarcinoma HepG2 line, during and after the exposure to 0.57-MHz CRET currents at subthermal densities. The electric stimuli provoked a decrease in the proliferation rate of the cultures, possibly due to an electrically-induced blocking of the cell cycle in a fraction of the cellular population.

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Copy and paste a formatted citation
Spandidos Publications style
Hernández-Bule ML, Trillo MÁ, Cid MA, Leal J and Úbeda A: In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells. Int J Oncol 30: 583-592, 2007.
APA
Hernández-Bule, M.L., Trillo, M.Á., Cid, M.A., Leal, J., & Úbeda, A. (2007). In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells. International Journal of Oncology, 30, 583-592. https://doi.org/10.3892/ijo.30.3.583
MLA
Hernández-Bule, M. L., Trillo, M. Á., Cid, M. A., Leal, J., Úbeda, A."In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells". International Journal of Oncology 30.3 (2007): 583-592.
Chicago
Hernández-Bule, M. L., Trillo, M. Á., Cid, M. A., Leal, J., Úbeda, A."In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells". International Journal of Oncology 30, no. 3 (2007): 583-592. https://doi.org/10.3892/ijo.30.3.583
Copy and paste a formatted citation
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Spandidos Publications style
Hernández-Bule ML, Trillo MÁ, Cid MA, Leal J and Úbeda A: In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells. Int J Oncol 30: 583-592, 2007.
APA
Hernández-Bule, M.L., Trillo, M.Á., Cid, M.A., Leal, J., & Úbeda, A. (2007). In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells. International Journal of Oncology, 30, 583-592. https://doi.org/10.3892/ijo.30.3.583
MLA
Hernández-Bule, M. L., Trillo, M. Á., Cid, M. A., Leal, J., Úbeda, A."In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells". International Journal of Oncology 30.3 (2007): 583-592.
Chicago
Hernández-Bule, M. L., Trillo, M. Á., Cid, M. A., Leal, J., Úbeda, A."In vitro exposure to 0.57-MHz electric currents exerts cytostatic effects in HepG2 human hepatocarcinoma cells". International Journal of Oncology 30, no. 3 (2007): 583-592. https://doi.org/10.3892/ijo.30.3.583
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