Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines

  • Authors:
    • A. Faried
    • D. Kurnia
    • L. S. Faried
    • N. Usman
    • T. Miyazaki
    • H. Kato
    • H. Kuwano
  • View Affiliations

  • Published online on: March 1, 2007     https://doi.org/10.3892/ijo.30.3.605
  • Pages: 605-613
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Abstract

The natural antioxidant gallic acid (GA) was isolated from fruits of a medicinal Indonesian plant, Phaleria macrocarpa (Scheff.) Boerl. The structure was identified on the basis of spectroscopic analysis and comparison with authentic compound. GA demonstrated a significant inhibition of cell proliferation in a series of cancer cell lines and induced apoptosis in esophageal cancer cells (TE-2) but not in non-cancerous cells (CHEK-1). Observation of the molecular mechanism of apoptosis showed that GA up-regulated the pro-apoptosis protein, Bax, and induced caspase-cascade activity in cancer cells. On the other hand, GA down-regulated anti-apoptosis proteins such as Bcl-2 and Xiap. In addition, GA also induced down-regulation of the survival Akt/mTOR pathway. In non-cancerous cells, we observed delayed expression of pro-apoptosis related proteins. Our results suggest that GA might be a potential anticancer compound. However, in depth in vivo studies are needed to elucidate the exact mechanism.

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March 2007
Volume 30 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H and Kuwano H: Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. Int J Oncol 30: 605-613, 2007
APA
Faried, A., Kurnia, D., Faried, L.S., Usman, N., Miyazaki, T., Kato, H., & Kuwano, H. (2007). Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines. International Journal of Oncology, 30, 605-613. https://doi.org/10.3892/ijo.30.3.605
MLA
Faried, A., Kurnia, D., Faried, L. S., Usman, N., Miyazaki, T., Kato, H., Kuwano, H."Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines". International Journal of Oncology 30.3 (2007): 605-613.
Chicago
Faried, A., Kurnia, D., Faried, L. S., Usman, N., Miyazaki, T., Kato, H., Kuwano, H."Anticancer effects of gallic acid isolated from Indonesian herbal medicine, Phaleria macrocarpa (Scheff.) Boerl, on human cancer cell lines". International Journal of Oncology 30, no. 3 (2007): 605-613. https://doi.org/10.3892/ijo.30.3.605