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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2007 Volume 31 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2007 Volume 31 Issue 6

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Article

p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?

  • Authors:
    • Ingrid Norman
    • Sophia Brismar
    • Jie Zhu
    • Vera Gaberi
    • Bjorn Hagmar
    • Anders Hjerpe
    • Sonia Andersson

  • View Affiliations / Copyright

    Affiliations: Laboratory of Clinical Pathology and Cytology, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden
  • Pages: 1339-1343
    |
    Published online on: December 1, 2007
       https://doi.org/10.3892/ijo.31.6.1339
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Abstract

A consecutive series of 118 samples from patients referred to colposcopy assessment and follow-up with cytology and biopsies were analysed with immunocytochemical staining to determinate the expression of p16INK4a. Accumulation of p16INK4a antigen has been proposed as a biomarker helpful for the identification of dysplastic cervical cells. In our study all benign cases were negative for p16INK4a, while more than half of the high grade lesions showed moderate or strong reactivity. There was a correlation between CIN grade and p16 INK4a expression levels with more advanced lesions showing stronger reactivity. The correlation between p16INK4a immunoreactivity and the severity of cytological abnormality was stronger, when the diagnosis was based on simultaneous routine cytology (p<0.001, χ2 exact test for trend). There was no or weak reactivity in benign cases, as well as almost all low-grade lesions, while two thirds of high-grade lesions showed moderate or strong staining for p16 INK4a antigen. Thus p16INK4a expression analysis yielded information which is consistent with results from the histopathology and is a simple way of emphasizing the presence of premalignant cell reactive atypias. This staining can be applied to cytological samples, and might be a complement prognostic procedure in order to find women at risk for cervical cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Norman I, Brismar S, Zhu J, Gaberi V, Hagmar B, Hjerpe A and Andersson S: p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?. Int J Oncol 31: 1339-1343, 2007.
APA
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., & Andersson, S. (2007). p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?. International Journal of Oncology, 31, 1339-1343. https://doi.org/10.3892/ijo.31.6.1339
MLA
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., Andersson, S."p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?". International Journal of Oncology 31.6 (2007): 1339-1343.
Chicago
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., Andersson, S."p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?". International Journal of Oncology 31, no. 6 (2007): 1339-1343. https://doi.org/10.3892/ijo.31.6.1339
Copy and paste a formatted citation
x
Spandidos Publications style
Norman I, Brismar S, Zhu J, Gaberi V, Hagmar B, Hjerpe A and Andersson S: p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?. Int J Oncol 31: 1339-1343, 2007.
APA
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., & Andersson, S. (2007). p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?. International Journal of Oncology, 31, 1339-1343. https://doi.org/10.3892/ijo.31.6.1339
MLA
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., Andersson, S."p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?". International Journal of Oncology 31.6 (2007): 1339-1343.
Chicago
Norman, I., Brismar, S., Zhu, J., Gaberi, V., Hagmar, B., Hjerpe, A., Andersson, S."p16INK4a immunocytochemistry in liquid-based cervical cytology: is it feasible for clinical use?". International Journal of Oncology 31, no. 6 (2007): 1339-1343. https://doi.org/10.3892/ijo.31.6.1339
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