Oncostatin M-induced genes in human astrocytomas

  • Authors:
    • Annika Krona
    • Pierre Åman
    • Charlotte Örndal
    • Agnetha Josefsson
  • View Affiliations

  • Published online on: December 1, 2007     https://doi.org/10.3892/ijo.31.6.1457
  • Pages: 1457-1463
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Abstract

Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) cytokine family and known to be induced in the nervous system as a result of cell stress. OSM is expressed in most human brain tumors, but the effects on tumor cells are unclear. The cytokine is known to activate the JAK/STAT signaling pathway by binding to its receptors gp130/OSMβ or gp130/LIFRβ and thereby initiating activation or suppression of a number of STAT target genes. The objective of the study was to identify OSM-regulated genes that could help in understanding the function of OSM in glioma cells. The glioma cell line, U1242MG was stimulated by OSM and the gene expression patterns were analyzed by microarray. In total, nineteen differentially expressed genes were selected due to high intensity, level of up/down-regulation and biological functions. The differentially expressed genes were verified using quantitative PCR. Additional validation of the confirmed OSM-induced proteins was performed in human astrocytoma tissues by immunohistochemistry. Among the up-regulated genes were CHI3L1, PLAU, MT2A and EPAS1. These genes are known to be involved in cell matrix remodeling, migration, proliferation control and angiogenesis. The results suggest that OSM induces genes that might contribute to the development and progression of astrocytomas.

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December 2007
Volume 31 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Krona A, Åman P, Örndal C and Josefsson A: Oncostatin M-induced genes in human astrocytomas. Int J Oncol 31: 1457-1463, 2007.
APA
Krona, A., Åman, P., Örndal, C., & Josefsson, A. (2007). Oncostatin M-induced genes in human astrocytomas. International Journal of Oncology, 31, 1457-1463. https://doi.org/10.3892/ijo.31.6.1457
MLA
Krona, A., Åman, P., Örndal, C., Josefsson, A."Oncostatin M-induced genes in human astrocytomas". International Journal of Oncology 31.6 (2007): 1457-1463.
Chicago
Krona, A., Åman, P., Örndal, C., Josefsson, A."Oncostatin M-induced genes in human astrocytomas". International Journal of Oncology 31, no. 6 (2007): 1457-1463. https://doi.org/10.3892/ijo.31.6.1457