Down-regulation of androgen-receptor and PSA by phytochemicals

  • Authors:
    • Sophie Chen
    • Jian Gao
    • H. Dorota Halicka
    • Frank Traganos
    • Zbigniew Darzynkiewicz
  • View Affiliations

  • Published online on: February 1, 2008     https://doi.org/10.3892/ijo.32.2.405
  • Pages: 405-411
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Abstract

The androgen receptor (AR) signaling pathway continues to be active in hormone resistant prostate cancer (HRPC) and can inappropriately activate transcription. Consequently the AR is a therapeutic target for HRPC. We reported that PC-SPES is active against HRPC, partly due to its actions in down-regulating AR protein expression and modulating cell cycle. Further investigation has identified five active anticancer compounds. This study describes the effects of three of these compounds (oridonin, isoliquiritigenin and wogonin) on cell proliferation, cell apoptosis, cell cycle parameters, AR and PSA protein expression. In each case, these compounds have independent activities which may partly contribute to the biological activity of PC-SPES.

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February 2008
Volume 32 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Chen S, Gao J, Halicka HD, Traganos F and Darzynkiewicz Z: Down-regulation of androgen-receptor and PSA by phytochemicals. Int J Oncol 32: 405-411, 2008
APA
Chen, S., Gao, J., Halicka, H.D., Traganos, F., & Darzynkiewicz, Z. (2008). Down-regulation of androgen-receptor and PSA by phytochemicals. International Journal of Oncology, 32, 405-411. https://doi.org/10.3892/ijo.32.2.405
MLA
Chen, S., Gao, J., Halicka, H. D., Traganos, F., Darzynkiewicz, Z."Down-regulation of androgen-receptor and PSA by phytochemicals". International Journal of Oncology 32.2 (2008): 405-411.
Chicago
Chen, S., Gao, J., Halicka, H. D., Traganos, F., Darzynkiewicz, Z."Down-regulation of androgen-receptor and PSA by phytochemicals". International Journal of Oncology 32, no. 2 (2008): 405-411. https://doi.org/10.3892/ijo.32.2.405