Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones

  • Authors:
    • Atsuko Ishikawa
    • Mitsuhiro Kudo
    • Nando Nakazawa
    • Munehiko Onda
    • Toshiyuki Ishiwata
    • Toshiyuki Takeshita
    • Zenya Naito
  • View Affiliations

  • Published online on: March 1, 2008     https://doi.org/10.3892/ijo.32.3.565
  • Pages: 565-574
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Abstract

The keratinocyte factor (KGF) and its receptor (KGFR) are implicated in tissue development and repair. We studied the expression and functions of KGF and KGFR in association with estrogen and progesterone in human endometrial tissues and cells. In non-cancerous human endometrial tissues in the secretory phase, a strong immunoreactivity of KGF in glands, stromal cells, and smooth muscle cells of spiral arteries was detected; however, in proliferative-phase tissues, the immunoreactivity of KGF or KGFR was weak or absent. Most of the 32 endometrioid adenocarcinoma cases showed positive KGF and KGFR stainings (90.6 and 71.9%, respectively). We then studied, using Ishikawa well-differentiated human endometrial cancer cell line that expresses estrogen receptor (ER) and progesterone receptor (PR), the expression of KGF and KGFR in conjunction with estrogen and progesterone, and observed that the KGFR expression of Ishikawa cells was upregulated by estrogen and that this upregulation was markedly enhanced by the coadministration of progesterone. We also observed that KGF administration to cells, with KGFR upregulated expression, stimulated ERK1/2 phosphorylation and cell adhesion to fibronectin. The implications of the hormone-stimulated KGF-KGFR expressions in the regulation of cell behavior associated with human endometrial cancer are discussed.

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March 2008
Volume 32 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ishikawa A, Kudo M, Nakazawa N, Onda M, Ishiwata T, Takeshita T and Naito Z: Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones. Int J Oncol 32: 565-574, 2008.
APA
Ishikawa, A., Kudo, M., Nakazawa, N., Onda, M., Ishiwata, T., Takeshita, T., & Naito, Z. (2008). Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones. International Journal of Oncology, 32, 565-574. https://doi.org/10.3892/ijo.32.3.565
MLA
Ishikawa, A., Kudo, M., Nakazawa, N., Onda, M., Ishiwata, T., Takeshita, T., Naito, Z."Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones". International Journal of Oncology 32.3 (2008): 565-574.
Chicago
Ishikawa, A., Kudo, M., Nakazawa, N., Onda, M., Ishiwata, T., Takeshita, T., Naito, Z."Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones". International Journal of Oncology 32, no. 3 (2008): 565-574. https://doi.org/10.3892/ijo.32.3.565