Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases

  • Authors:
    • Hiroyuki Yoshidome
    • Hirohiko Kohno
    • Takashi Shida
    • Fumio Kimura
    • Hiroaki Shimizu
    • Masayuki Ohtsuka
    • Yukio Nakatani
    • Masaru Miyazaki
  • View Affiliations

  • Published online on: April 1, 2009     https://doi.org/10.3892/ijo_00000218
  • Pages: 923-930
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Abstract

Monocyte chemoattractant protein-1 (MCP-1) has been demonstrated to play a role in tumor progression. The present study examined the MCP-1 expression of colorectal liver metastases and determined whether MCP-1 is related to tumor progression and is a predictive marker for survival after hepatic resection of colorectal liver metastases. Eighty-seven patients with colorectal liver metastases were evaluated by immunohistochemistry of MCP-1, Angiopoietin-2, CD68, and CD34 for determination of microvessel density. Clinicopatholgical data were also examined. In a separate experiment, immunohistochemistry of MCP-1 was performed to investigate the expression of primary colorectal tumor according to the clinical stage. MCP-1 mRNA expression was determined in colorectal cancer cell lines. Forty-nine patients (56%) showed high expression of MCP-1 of colorectal liver metastases. High MCP-1 expression was related to multiple colorectal liver metastases. When the degree of MCP-1 expression increased, microvessel density count significantly increased compared with low MCP-1 expression. The MCP-1 expression correlated with Angiopoietin-2 expression. MCP-1 expression of the primary colorectal cancer increased as the clinical stage advanced. The increased MCP-1 mRNA expression was observed in cancer cell lines which have high metastasis potency. Univariate analysis demonstrated that the timing of metastases, tumor size, number of metastases, and MCP-1 expression were significant prognostic factors. Multivariate analysis demonstrated that MCP-1 expression was a significant prognostic factor in hepatic disease-free survival. The MCP-1 expression in colorectal liver metastases, at least in part, may be associated with angiogenesis and be a predictive marker for hepatic recurrence after hepatic resection for colorectal liver metastases.

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April 2009
Volume 34 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yoshidome, H., Kohno, H., Shida, T., Kimura, F., Shimizu, H., Ohtsuka, M. ... Miyazaki, M. (2009). Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases. International Journal of Oncology, 34, 923-930. https://doi.org/10.3892/ijo_00000218
MLA
Yoshidome, H., Kohno, H., Shida, T., Kimura, F., Shimizu, H., Ohtsuka, M., Nakatani, Y., Miyazaki, M."Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases". International Journal of Oncology 34.4 (2009): 923-930.
Chicago
Yoshidome, H., Kohno, H., Shida, T., Kimura, F., Shimizu, H., Ohtsuka, M., Nakatani, Y., Miyazaki, M."Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases". International Journal of Oncology 34, no. 4 (2009): 923-930. https://doi.org/10.3892/ijo_00000218