Role of RLIP76 in doxorubicin resistance in lung cancer (Review)

  • Authors:
    • Rit Vatsyayan
    • Pankaj Chaudhary
    • Poorna Chandra Rao Lelsani
    • Preeti Singhal
    • Yogesh C. Awasthi
    • Sanjay Awasthi
    • Sharad S. Singhal
  • View Affiliations

  • Published online on: Monday, June 1, 2009
  • Pages: 1505-1511 DOI: 10.3892/ijo_00000279

Abstract

Lung cancer is still a major cause of cancer deaths in spite of considerable efforts in its systemic therapy. Chemotherapy, along with local irradiation is frequently employed but as a palliative therapy. Inherent and acquired resistance in NSCLC and SCLC towards chemotherapeutic agents further makes chemotherapy an incommodious problem. The resistance mechanisms responsible for inherent DOX-resistance of NSCLC and acquired DOX-resistance in SCLC have been the subject of numerous investigations. This review will focus on the recent studies done for understanding the mechanism(s) of inherent and acquired resistance in NSCLC and SCLC and how these can be exploited for the future development of more effective novel biologic agents for the treatment of lung cancer.

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June 2009
Volume 34 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

2015 Impact Factor: 3.018
Ranked #30/211 Oncology
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APA
Vatsyayan, R., Chaudhary, P., Lelsani, P.C., Singhal, P., Awasthi, Y.C., Awasthi, S., & Singhal, S.S. (2009). Role of RLIP76 in doxorubicin resistance in lung cancer (Review). International Journal of Oncology, 34, 1505-1511. http://dx.doi.org/10.3892/ijo_00000279
MLA
Vatsyayan, R., Chaudhary, P., Lelsani, P. C., Singhal, P., Awasthi, Y. C., Awasthi, S., Singhal, S. S."Role of RLIP76 in doxorubicin resistance in lung cancer (Review)". International Journal of Oncology 34.6 (2009): 1505-1511.
Chicago
Vatsyayan, R., Chaudhary, P., Lelsani, P. C., Singhal, P., Awasthi, Y. C., Awasthi, S., Singhal, S. S."Role of RLIP76 in doxorubicin resistance in lung cancer (Review)". International Journal of Oncology 34, no. 6 (2009): 1505-1511. http://dx.doi.org/10.3892/ijo_00000279