search button

Regulatory T cells actively infiltrate metastatic brain tumors

  • Authors:
    • Adam Quasar Sugihara
    • Cleo E. Rolle
    • Maciej S. Lesniak

  • View Affiliations

  • Published online on: June 1, 2009     https://doi.org/10.3892/ijo_00000282
  • Pages: 1533-1540
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Regulatory T cells (CD4+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ and Treg infiltration are significantly increased throughout the time of metastatic tumor progression. These findings were recapitulated in human CNS tumor samples of metastatic melanoma and non-small cell lung carcinoma. Collectively, these data support investigating immunotherapeutic strategies targeting Treg in metastatic CNS tumors.

Related Articles

Journal Cover

June 2009
Volume 34 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.2
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Sugihara AQ, Rolle CE and Lesniak MS: Regulatory T cells actively infiltrate metastatic brain tumors. Int J Oncol 34: 1533-1540, 2009
APA
Sugihara, A.Q., Rolle, C.E., & Lesniak, M.S. (2009). Regulatory T cells actively infiltrate metastatic brain tumors. International Journal of Oncology, 34, 1533-1540. https://doi.org/10.3892/ijo_00000282
MLA
Sugihara, A. Q., Rolle, C. E., Lesniak, M. S."Regulatory T cells actively infiltrate metastatic brain tumors". International Journal of Oncology 34.6 (2009): 1533-1540.
Chicago
Sugihara, A. Q., Rolle, C. E., Lesniak, M. S."Regulatory T cells actively infiltrate metastatic brain tumors". International Journal of Oncology 34, no. 6 (2009): 1533-1540. https://doi.org/10.3892/ijo_00000282