Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

  • Authors:
    • Girolamo Ranieri
    • Michele Ammendola
    • Rosa Patruno
    • Giuseppe Celano
    • Francesco Alfredo Zito
    • Severino Montemurro
    • Addolorata Rella
    • Valentina Di Lecce
    • Cosmo Damiano Gadaleta
    • Giovanni Battista De Sarro
    • Domenico Ribatti
  • View Affiliations

  • Published online on: Wednesday, July 1, 2009
  • Pages: 115-120 DOI: 10.3892/ijo_00000319
0

Abstract

Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MCs granules, is one of the most active. However, no data are available concerning the role of MCs in angiogenesis in primary human breast cancer. In this study, we have evaluated the correlations between the number of MCs positive to tryptase (MCDPT), the area occupied by MCs positive to tryptase (MCAPT) and microvascular density (MVD) and endothelial area (EA) in a series of 88 primary T1-3, N0-2 M0 female breast cancer, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant (r = from 0.78 to 0.89; p-value from 0.001 to 0.002 by Pearson's analysis respectively) correlation between MCDPT, MCAPT, MVD, EA to each other. No correlation concerning MCDPT, MCAPT, MVD, EA and the main clinicopathological features was found. Our results suggest that tryptase-positive MCs play a role in breast cancer angiogenesis. In this context several tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new anti-angiogenetic approach.

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July 2009
Volume 35 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

2015 Impact Factor: 3.018
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Copy and paste a formatted citation
APA
Ranieri, G., Ammendola, M., Patruno, R., Celano, G., Zito, F.A., Montemurro, S. ... Ribatti, D. (2009). Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. International Journal of Oncology, 35, 115-120. http://dx.doi.org/10.3892/ijo_00000319
MLA
Ranieri, G., Ammendola, M., Patruno, R., Celano, G., Zito, F. A., Montemurro, S., Rella, A., Di Lecce, V., Gadaleta, C. D., Battista De Sarro, G., Ribatti, D."Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients". International Journal of Oncology 35.1 (2009): 115-120.
Chicago
Ranieri, G., Ammendola, M., Patruno, R., Celano, G., Zito, F. A., Montemurro, S., Rella, A., Di Lecce, V., Gadaleta, C. D., Battista De Sarro, G., Ribatti, D."Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients". International Journal of Oncology 35, no. 1 (2009): 115-120. http://dx.doi.org/10.3892/ijo_00000319