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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2009 Volume 35 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 35 Issue 3

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Article

Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer

  • Authors:
    • Takumi Endo
    • Katsuhiro Uzawa
    • Hiroyoshi Suzuki
    • Hideki Tanzawa
    • Tomohiko Ichikawa

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan
  • Pages: 499-509
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijo_00000361
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Abstract

The molecular mechanism playing a role in the development of benign prostate hypertrophy (BPH) and prostate cancer (PC) is not well defined. We performed microarray analysis to assess the gene expression change in BPH and PC, and performed network analysis. Normal prostate, BPH and PC tissues were obtained from patients who underwent an operation at Chiba University Hospital. Using Affymetrix Human Genome U133 Plus2.0 Array, we identified genes differentially expressed. The identified genes were analyzed using the Ingenuity Pathway Analysis (IPA) to investigate the functional network and gene ontology. The microarray analysis identified 402 genes in BPH and 141 genes in PC, which were up- or down-regulated at least 5.0-fold change in PC at all dose points. Analysis using IPA software revealed eight networks in BPH and five networks in PC. We narrowed these down to the top five genes, which were up- or down-regulated on the networks in their characteristic manner. From this new perspective, comparing BPH and PC in microarray studies, our data showing gene expression profiles provide candidate genes for better understanding of disease and new therapeutic targets.

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Copy and paste a formatted citation
Spandidos Publications style
Endo T, Uzawa K, Suzuki H, Tanzawa H and Ichikawa T: Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer. Int J Oncol 35: 499-509, 2009.
APA
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., & Ichikawa, T. (2009). Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer. International Journal of Oncology, 35, 499-509. https://doi.org/10.3892/ijo_00000361
MLA
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., Ichikawa, T."Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer". International Journal of Oncology 35.3 (2009): 499-509.
Chicago
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., Ichikawa, T."Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer". International Journal of Oncology 35, no. 3 (2009): 499-509. https://doi.org/10.3892/ijo_00000361
Copy and paste a formatted citation
x
Spandidos Publications style
Endo T, Uzawa K, Suzuki H, Tanzawa H and Ichikawa T: Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer. Int J Oncol 35: 499-509, 2009.
APA
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., & Ichikawa, T. (2009). Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer. International Journal of Oncology, 35, 499-509. https://doi.org/10.3892/ijo_00000361
MLA
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., Ichikawa, T."Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer". International Journal of Oncology 35.3 (2009): 499-509.
Chicago
Endo, T., Uzawa, K., Suzuki, H., Tanzawa, H., Ichikawa, T."Characteristic gene expression profiles of benign prostatic hypertrophy and prostate cancer". International Journal of Oncology 35, no. 3 (2009): 499-509. https://doi.org/10.3892/ijo_00000361
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