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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2009 Volume 35 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 35 Issue 3

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Article

Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome

  • Authors:
    • Carol E. Jolly
    • Lindsey J. Gray
    • Joanna L. Parish
    • Sonia Lain
    • C. Simon Herrington

  • View Affiliations / Copyright

    Affiliations: Bute Medical School, University of St Andrews, Westburn Lane, St Andrews, Fife, KY16 9TS, UK
  • Pages: 649-656
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijo_00000377
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Abstract

Cervical cancer is a major cause of death in women worldwide and is strongly associated with human papillomavirus (HPV) infection. Integration of HPV is thought to be a key step in malignant progression, and is associated with loss of regulation of the viral E6 and E7 oncogenes. Leptomycin B (LMB), a nuclear export inhibitor, has previously been shown to induce apoptosis in primary keratinocytes transduced with the HPV 16 E7 or E6/E7 genes, but not in normal cells. We show here that LMB can also induce apoptosis in derivatives of the W12 cell line that contain either episomal or integrated HPV 16. Cells transduced with HPV 16 E7 or E6/E7, and the episomal and integrated W12 derivatives showed distinct temporal expression patterns of the apoptotic markers activated caspase-3 and M30. The expression of both markers occurred later in the episomal derivatives than in either transduced cells or W12 derivatives containing integrated HPV. These findings suggest that, although LMB can induce apoptosis in keratinocytes containing episomal or integrated HPV 16, genome status is likely to influence the response of HPV-associated anogenital lesions to LMB treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Jolly CE, Gray LJ, Parish JL, Lain S and Herrington CS: Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome. Int J Oncol 35: 649-656, 2009.
APA
Jolly, C.E., Gray, L.J., Parish, J.L., Lain, S., & Herrington, C.S. (2009). Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome. International Journal of Oncology, 35, 649-656. https://doi.org/10.3892/ijo_00000377
MLA
Jolly, C. E., Gray, L. J., Parish, J. L., Lain, S., Herrington, C. S."Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome". International Journal of Oncology 35.3 (2009): 649-656.
Chicago
Jolly, C. E., Gray, L. J., Parish, J. L., Lain, S., Herrington, C. S."Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome". International Journal of Oncology 35, no. 3 (2009): 649-656. https://doi.org/10.3892/ijo_00000377
Copy and paste a formatted citation
x
Spandidos Publications style
Jolly CE, Gray LJ, Parish JL, Lain S and Herrington CS: Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome. Int J Oncol 35: 649-656, 2009.
APA
Jolly, C.E., Gray, L.J., Parish, J.L., Lain, S., & Herrington, C.S. (2009). Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome. International Journal of Oncology, 35, 649-656. https://doi.org/10.3892/ijo_00000377
MLA
Jolly, C. E., Gray, L. J., Parish, J. L., Lain, S., Herrington, C. S."Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome". International Journal of Oncology 35.3 (2009): 649-656.
Chicago
Jolly, C. E., Gray, L. J., Parish, J. L., Lain, S., Herrington, C. S."Leptomycin B induces apoptosis in cells containing the whole HPV 16 genome". International Journal of Oncology 35, no. 3 (2009): 649-656. https://doi.org/10.3892/ijo_00000377
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