Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8

  • Authors:
    • Koji Harada
    • Tarannum Ferdous
    • Yasutaka Itashiki
    • Michiyo Takii
    • Takamichi Mano
    • Yoshihide Mori
    • Yoshiya Ueyama
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/ijo_00000417
  • Pages: 1025-1035
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Abstract

Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases, and can exert antitumor effects on several human cancer cell lines. However, little is known about the detailed mechanisms of the antitumor activity of Cepharanthine. In the present study, we determined whether Cepharanthine could suppress angiogenesis and growth of human oral squamous cell carcinoma (OSCC) cells in vitro and in vivo. Cepharanthine significantly inhibited expression of two major pro-angiogenic molecules, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), in cultured cells and in cells implanted into the subcutaneous tissue of nude mice. Also, Cepharanthine inhibited the nuclear factor-κB (NF-κB) activity in human OSCC cells in vitro and in vivo. The decreased expression of VEGF and IL-8 correlated with decreased tumor cell growth and decreased vascularization in vitro and in vivo. These findings suggest that Cepharanthine can suppress angiogenesis and growth of OSCC cells by inhibiting expression of VEGF and IL-8 involved in the blockade of NF-κB activity.

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November 2009
Volume 35 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Harada K, Ferdous T, Itashiki Y, Takii M, Mano T, Mori Y and Ueyama Y: Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8. Int J Oncol 35: 1025-1035, 2009
APA
Harada, K., Ferdous, T., Itashiki, Y., Takii, M., Mano, T., Mori, Y., & Ueyama, Y. (2009). Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8. International Journal of Oncology, 35, 1025-1035. https://doi.org/10.3892/ijo_00000417
MLA
Harada, K., Ferdous, T., Itashiki, Y., Takii, M., Mano, T., Mori, Y., Ueyama, Y."Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8". International Journal of Oncology 35.5 (2009): 1025-1035.
Chicago
Harada, K., Ferdous, T., Itashiki, Y., Takii, M., Mano, T., Mori, Y., Ueyama, Y."Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8". International Journal of Oncology 35, no. 5 (2009): 1025-1035. https://doi.org/10.3892/ijo_00000417