Phosphoglucose isomerase enhances colorectal cancer metastasis

  • Authors:
    • Soichi Tsutsumi
    • Takaharu Fukasawa
    • Hayato Yamauchi
    • Toshihide Kato
    • Wakako Kigure
    • Hiroki Morita
    • Takayuki Asao
    • Hiroyuki Kuwano
  • View Affiliations

  • Published online on: November 1, 2009     https://doi.org/10.3892/ijo_00000427
  • Pages: 1117-1121
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Abstract

Phosphoglucose isomerase (PGI) is a ubiquitous cytosolic enzyme that plays a key role in glycolysis. PGI is also a multifunctional protein that acts in the extracellular milieu as a potent mitogen/cytokine. Increased expression of PGI and its receptor has been found in a wide spectrum of malignancies and is associated with cancer progression and metastasis. In this study, the role of PGI in the growth and metastasis of colon cancer cells was determined. To elucidate the functional role of PGI in colorectal cancer, we stably transfected PGI cDNA into human colon cancer cells. We used an orthotopic mouse tumor model to assess whether overexpression of PGI enhances liver metastasis. Overexpression of PGI stimulated the in vitro invasion of DLD-1 cells. In vivo, after orthotopic implantation into the cecum of nude mice, parental and empty vector-transfected DLD-1 cells produced small tumors without liver metastasis, whereas PGI-overexpressing DLD-1 cells produced large tumors and liver metastases. In conclusion, overexpression of PGI significantly contributes to the aggressive phenotype of human colon cancer and, thus, may provide a novel therapeutic target.

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November 2009
Volume 35 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Tsutsumi, S., Fukasawa, T., Yamauchi, H., Kato, T., Kigure, W., Morita, H. ... Kuwano, H. (2009). Phosphoglucose isomerase enhances colorectal cancer metastasis. International Journal of Oncology, 35, 1117-1121. https://doi.org/10.3892/ijo_00000427
MLA
Tsutsumi, S., Fukasawa, T., Yamauchi, H., Kato, T., Kigure, W., Morita, H., Asao, T., Kuwano, H."Phosphoglucose isomerase enhances colorectal cancer metastasis". International Journal of Oncology 35.5 (2009): 1117-1121.
Chicago
Tsutsumi, S., Fukasawa, T., Yamauchi, H., Kato, T., Kigure, W., Morita, H., Asao, T., Kuwano, H."Phosphoglucose isomerase enhances colorectal cancer metastasis". International Journal of Oncology 35, no. 5 (2009): 1117-1121. https://doi.org/10.3892/ijo_00000427