Association of H-ras polymorphisms and susceptibility to sporadic colon cancer

  • Authors:
    • Tina Catela Ivkovic
    • Bozo Loncar
    • Radan Spaventi
    • Sanja Kapitanovic
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  • Published online on: November 1, 2009     https://doi.org/10.3892/ijo_00000433
  • Pages: 1169-1173
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Abstract

High incidence of colon cancer worldwide indicates the importance of studying genetic alterations that lead to its carcinogenesis. Two polymorphisms in H-ras gene, hexanucleotide tandem repeats in the first intron and SNP 81T>C in the first exon, that might be connected with susceptibility to cancer have been described. The aim of our study was to investigate these loci in Croatian population and to determine if any of them is connected with susceptibility to colon cancer in our population. Two hundred healthy volunteers and 200 colon cancer patients were genotyped using PCR and RFLP methods. We noted statistically significant difference in genotype distribution at hexanucleotide locus between healthy population and colon cancer patients (p=0.013) but not in allelic distribution. At SNP 81 T>C statistically significant difference in distribution of both genotypes (p=9.15x10−6) and alleles (p=2.77x10−6) was found. No differences were found between genders.

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November 2009
Volume 35 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Catela Ivkovic, T., Loncar, B., Spaventi, R., & Kapitanovic, S. (2009). Association of H-ras polymorphisms and susceptibility to sporadic colon cancer. International Journal of Oncology, 35, 1169-1173. https://doi.org/10.3892/ijo_00000433
MLA
Catela Ivkovic, T., Loncar, B., Spaventi, R., Kapitanovic, S."Association of H-ras polymorphisms and susceptibility to sporadic colon cancer". International Journal of Oncology 35.5 (2009): 1169-1173.
Chicago
Catela Ivkovic, T., Loncar, B., Spaventi, R., Kapitanovic, S."Association of H-ras polymorphisms and susceptibility to sporadic colon cancer". International Journal of Oncology 35, no. 5 (2009): 1169-1173. https://doi.org/10.3892/ijo_00000433