ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling

  • Authors:
    • Hae-Young Yong
    • In-Young Kim
    • Jong Suk Kim
    • Aree Moon
  • View Affiliations

  • Published online on: February 1, 2010     https://doi.org/10.3892/ijo_00000524
  • Pages: 501-507
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Abstract

Overexpression of ErbB2 has been frequently found in mammary carcinoma. We have previously shown that the aberrant activation of H-Ras induces human breast cell invasion and migration. The present study was aimed at investigating the effect of ErbB2 overexpression on H-Ras-induced breast cell invasion and to elucidate the underlying mechanisms. Herein, we show that overexpression of ErbB2 promotes invasive and migratory abilities of H-Ras-activated MCF10A human breast epithelial cells through upregulation of matrix metalloproteinase (MMP)-13 and urokinase-type plasminogen activator (uPA). We also demonstrate that the p38 MAPK is an important signaling molecule in the ErbB2-induced upregulation of MMP-13 and uPA and invasion/migration of H-Ras MCF10A cells overexpressing ErbB2. The present study elucidating the molecular mechanism underlying ErbB2-induced promotion of H-Ras MCF10A cell invasion may provide invaluable information for understanding breast cancer progression and establishing therapeutic interventions for breast cancer.

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February 2010
Volume 36 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yong H, Kim I, Kim JS and Moon A: ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling. Int J Oncol 36: 501-507, 2010
APA
Yong, H., Kim, I., Kim, J.S., & Moon, A. (2010). ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling. International Journal of Oncology, 36, 501-507. https://doi.org/10.3892/ijo_00000524
MLA
Yong, H., Kim, I., Kim, J. S., Moon, A."ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling". International Journal of Oncology 36.2 (2010): 501-507.
Chicago
Yong, H., Kim, I., Kim, J. S., Moon, A."ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling". International Journal of Oncology 36, no. 2 (2010): 501-507. https://doi.org/10.3892/ijo_00000524