Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review)

  • Authors:
    • Tibor Görögh
    • Ulf Henning Beier
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/ijo_00000526
  • Pages: 525-532
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Abstract

Head and neck squamous cell carcinoma (HNSCC) survival remains poor despite continuing efforts toward prevention, early detection, and improved treatment modalities. In part, this is thought to be due to a relative lack of molecular targeted therapeutic strategies beyond general mitosis inhibition, which sets a limit to what modern head and neck surgery can accomplish for advanced disease. The past 30 years have produced a large quantity of data, leading to a better understanding of HNSCC carcinogenesis and novel therapeutic agents, such as epidermal growth factor receptor blockers. This article reviews literature on the current understanding of molecular HNSCC carcinogenesis, and highlights the most promising therapeutic approaches.

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March 2010
Volume 36 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Görögh T and Görögh T: Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review). Int J Oncol 36: 525-532, 2010
APA
Görögh, T., & Görögh, T. (2010). Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review). International Journal of Oncology, 36, 525-532. https://doi.org/10.3892/ijo_00000526
MLA
Görögh, T., Beier, U. H."Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review)". International Journal of Oncology 36.3 (2010): 525-532.
Chicago
Görögh, T., Beier, U. H."Gene alterations in head and neck carcinomas and their role in promoting malignant behavior (Review)". International Journal of Oncology 36, no. 3 (2010): 525-532. https://doi.org/10.3892/ijo_00000526