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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2011 Volume 38 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 38 Issue 2

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Article

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

  • Authors:
    • Sung-Jun Lee
    • Hyo-Jeong Noh
    • Eon-Gi Sung
    • In-Hwan Song
    • Joo-Young Kim
    • Taeg Kyu Kwon
    • Tae-Jin Lee

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, College of Medicine, Yeungnam University, 317-1 Daemyung-Dong Nam-Gu, Daegu 705-717, Republic of Korea
  • Pages: 485-492
    |
    Published online on: December 17, 2010
       https://doi.org/10.3892/ijo.2010.878
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Abstract

Berberine (BBR) is an isoquinoline alkaloid which has a wide spectrum of clinical applications including anti-tumor, anti-microbial and anti-inflammatory activities. In this study, we showed that co-treatment with subtoxic doses of BBR and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human renal cancer cells, Caki cells, but not in normal tubular kidney cells. Treatment of Caki cells with BBR resulted in downregulation of c-FLIP and Mcl-1 proteins in a dose-dependent manner. The BBR-induced downregulation of c-FLIP and Mcl-1 proteins were involved in proteasome dependent pathways, which was confirmed by the result that pre-treatment with the proteasome inhibitor MG132 inhibited berberine-induced downregulation of the c-FLIP and Mcl-1 proteins. Pretreatment with N-acetyl-l-cysteine (NAC) significantly inhibited the cell death induced by the combined treatment with BBR and TRAIL as well as recovered the expression levels of c-FLIP and Mcl-1 downregulated by treatment with BBR. These results suggested that BBR-stimulated TRAIL-induced apoptosis is dependent on the generation of reactive oxygen species through the downregulation of c-FLIP and Mcl-1 proteins. In conclusion, this study demonstrates that BBR enhances TRAIL-induced apoptosis in human renal cancer cells by ROS-mediated c-FLIP and Mcl-1 down-regulation.

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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Noh H, Sung E, Song I, Kim J, Kwon TK and Lee T: Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. Int J Oncol 38: 485-492, 2011.
APA
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T.K., & Lee, T. (2011). Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. International Journal of Oncology, 38, 485-492. https://doi.org/10.3892/ijo.2010.878
MLA
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T. K., Lee, T."Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins". International Journal of Oncology 38.2 (2011): 485-492.
Chicago
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T. K., Lee, T."Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins". International Journal of Oncology 38, no. 2 (2011): 485-492. https://doi.org/10.3892/ijo.2010.878
Copy and paste a formatted citation
x
Spandidos Publications style
Lee S, Noh H, Sung E, Song I, Kim J, Kwon TK and Lee T: Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. Int J Oncol 38: 485-492, 2011.
APA
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T.K., & Lee, T. (2011). Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. International Journal of Oncology, 38, 485-492. https://doi.org/10.3892/ijo.2010.878
MLA
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T. K., Lee, T."Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins". International Journal of Oncology 38.2 (2011): 485-492.
Chicago
Lee, S., Noh, H., Sung, E., Song, I., Kim, J., Kwon, T. K., Lee, T."Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins". International Journal of Oncology 38, no. 2 (2011): 485-492. https://doi.org/10.3892/ijo.2010.878
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