Anti-adult T-cell leukemia effects of Bidens pilosa

  • Authors:
    • Shinji Nakama
    • Chie Ishikawa
    • Sawako Nakachi
    • Naoki Mori
  • View Affiliations

  • Published online on: February 10, 2011     https://doi.org/10.3892/ijo.2011.939
  • Pages: 1163-1173
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Abstract

We evaluated the effects of Bidens pilosa, a plant found in tropical and subtropical regions, and investigated the molecular pathways responsible for the anti-adult T-cell leukemia (ATL) effect. Water extracts of B. pilosa had growth suppressive effects on human T-cell leukemia virus type 1 (HTLV-1)-infected T-cell lines and ATL cells. B. pilosa extracts arrested cells in G1 cell cycle and induced apoptosis of HTLV-1-infected T-cell lines. B. pilosa extracts inhibited also the phosphorylation of IκB kinase β and IκBα, and NF-κB-DNA binding, in conjunction with reduction of expression of proteins involved in G1/S cell cycle transition and suppression of apoptosis. Reactive oxygen species played a role in B. pilosa-mediated suppression of NF-κB activity. B. pilosa extracts also inhibited the expression of JunB and JunD, resulting in suppression of AP-1-DNA binding. In animals harboring tumors of HTLV-1-infected T-cell origin, treatment with B. pilosa extracts suppressed tumor growth. Our results suggest that B. pilosa is a potentially useful medicinal plant for treatment of ATL.

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April 2011
Volume 38 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Nakama, S., Ishikawa, C., Nakachi, S., & Mori, N. (2011). Anti-adult T-cell leukemia effects of Bidens pilosa. International Journal of Oncology, 38, 1163-1173. https://doi.org/10.3892/ijo.2011.939
MLA
Nakama, S., Ishikawa, C., Nakachi, S., Mori, N."Anti-adult T-cell leukemia effects of Bidens pilosa". International Journal of Oncology 38.4 (2011): 1163-1173.
Chicago
Nakama, S., Ishikawa, C., Nakachi, S., Mori, N."Anti-adult T-cell leukemia effects of Bidens pilosa". International Journal of Oncology 38, no. 4 (2011): 1163-1173. https://doi.org/10.3892/ijo.2011.939