microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)

  • Authors:
    • May Y.W. Wong
    • Yan Yu
    • William R. Walsh
    • Jia-Lin Yang
  • View Affiliations

  • Published online on: Thursday, March 10, 2011
  • Pages: 1189-1195 DOI: 10.3892/ijo.2011.970
0

Abstract

In the last decade, microRNAs (miRNAs; small noncoding RNA molecules) as post-transcriptional regulators have been a hotspot in research for their involvement in biological processes and tumour development. However, there have been few reviews focusing on a single miRNA family. The dysregulation of miRNAs appears to play a crucial role in cancer pathogenesis where they exert their effect as oncogenes or as tumour suppressors. This review summarises current studies on the dysregulation of the microRNA-34 (miR-34) family in different types of cancers and its role in the p53 network. The structure of the miR-34 family members includes p53-binding sites reflecting their function as tumour suppressors downstream of the p53 pathway. miR-34 dysregulation occurs in cancers, including several epithelial cancers, melanomas, neuroblastomas, leukemias and sarcomas, in the presence or absence of the p53 mutation. For these cancers, functional restoration of miR-34 is a useful novel therapy. As evidenced from preclinical and clinical studies, the miR-34 family plays an important role in the treatment of miR-34-dysregulated cancers with mutant or wild-type p53. This review will have a potential impact in the clinical treatment of p53-mutant and/or miR-34-dysregulated cancers using a miR-34 restoration approach.

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May 2011
Volume 38 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2015 Impact Factor: 3.018
Ranked #30/211 Oncology
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APA
Wong, M.Y., Yu, Y., Walsh, W.R., & Yang, J. (2011). microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review). International Journal of Oncology, 38, 1189-1195. http://dx.doi.org/10.3892/ijo.2011.970
MLA
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38.5 (2011): 1189-1195.
Chicago
Wong, M. Y., Yu, Y., Walsh, W. R., Yang, J."microRNA-34 family and treatment of cancers with mutant or wild-type p53 (Review)". International Journal of Oncology 38, no. 5 (2011): 1189-1195. http://dx.doi.org/10.3892/ijo.2011.970