MicroRNA miR-125b is a prognostic marker in human colorectal cancer

  • Authors:
    • Naohiro Nishida
    • Takehiko Yokobori
    • Koshi Mimori
    • Tomoya Sudo
    • Fumiaki Tanaka
    • Kohei Shibata
    • Hideshi Ishii
    • Yuichiro Doki
    • Hiroyuki Kuwano
    • Masaki Mori
  • View Affiliations

  • Published online on: March 10, 2011     https://doi.org/10.3892/ijo.2011.969
  • Pages:1437-1443
0

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PCR was used to evaluate miR-125b expression in 89 colorectal cancer cases to determine the clinicopathological significance of miR-125b expression. The high miR-125b expression group showed a greater incidence of advanced tumor size and tumor invasion compared to the low miR-125b expression group (P<0.05). In addition, the high miR-125b expression group had a significantly poorer prognosis compared to the low expression group (P<0.05). Multivariate analysis indicated that high miR-125b expression was an independent prognostic factor for survival. Our analysis of miR-125b focused on the miR-125b/p53 pathway. In vitro assays revealed that overexpression of miR-125b repressed the endogenous level of p53 protein in human colorectal cancer cells. These data show that miR-125b is directly involved in cancer progression and is associated with poor prognosis in human colorectal cancer. Our findings suggest that miR-125b could be an important prognostic indicator for colorectal cancer patients.

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May 2011
Volume 38 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

2016 Impact Factor: 3.079
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APA
Nishida, N., Yokobori, T., Mimori, K., Sudo, T., Tanaka, F., Shibata, K. ... Mori, M. (2011). MicroRNA miR-125b is a prognostic marker in human colorectal cancer. International Journal of Oncology, 38, 1437-1443. https://doi.org/10.3892/ijo.2011.969
MLA
Nishida, N., Yokobori, T., Mimori, K., Sudo, T., Tanaka, F., Shibata, K., Ishii, H., Doki, Y., Kuwano, H., Mori, M."MicroRNA miR-125b is a prognostic marker in human colorectal cancer". International Journal of Oncology 38.5 (2011): 1437-1443.
Chicago
Nishida, N., Yokobori, T., Mimori, K., Sudo, T., Tanaka, F., Shibata, K., Ishii, H., Doki, Y., Kuwano, H., Mori, M."MicroRNA miR-125b is a prognostic marker in human colorectal cancer". International Journal of Oncology 38, no. 5 (2011): 1437-1443. https://doi.org/10.3892/ijo.2011.969