SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer

  • Authors:
    • Carl C. Schimanski
    • Mareike Jordan
    • Friederike Schlaegel
    • Irene Schmidtmann
    • Hauke Lang
    • Peter R. Galle
    • Markus Moehler
    • Ines Gockel
  • View Affiliations

  • Published online on: May 16, 2011     https://doi.org/10.3892/ijo.2011.1044
  • Pages: 515-520
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Abstract

We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR and PCR-RFLP in 69 consecutive fresh-frozen samples of human esophagogastric junction and gastric adenocarcinomas and statistically analyzed. Expression of the CXCL12 (SNP rs1801157) polymorphisms GA/AA significantly correlated with distant metastasis (P=0.026), but not with prognosis. However, CXCL12 expression was not significantly associated with the tumor infiltration depth, lymphatic metastasis and grading. As CXCL12 polymorphisms mediate tumor cell dissemination in esophagogastric cancer, they could represent a marker indicating advanced disease. Antagonists targeting the CXCL12/ CXCR4 axis may be a novel therapeutic option in this entity.

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August 2011
Volume 39 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Schimanski, C.C., Jordan, M., Schlaegel, F., Schmidtmann, I., Lang, H., Galle, P.R. ... Gockel, I. (2011). SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer . International Journal of Oncology, 39, 515-520. https://doi.org/10.3892/ijo.2011.1044
MLA
Schimanski, C. C., Jordan, M., Schlaegel, F., Schmidtmann, I., Lang, H., Galle, P. R., Moehler, M., Gockel, I."SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer ". International Journal of Oncology 39.2 (2011): 515-520.
Chicago
Schimanski, C. C., Jordan, M., Schlaegel, F., Schmidtmann, I., Lang, H., Galle, P. R., Moehler, M., Gockel, I."SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer ". International Journal of Oncology 39, no. 2 (2011): 515-520. https://doi.org/10.3892/ijo.2011.1044