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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2011 Volume 39 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2011 Volume 39 Issue 3

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Article

Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer

  • Authors:
    • Yasuhiro Tada
    • Akira Yokomizo
    • Masaki Shiota
    • Toshiyuki Tsunoda
    • Christoph Plass
    • Seiji Naito

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
  • Pages: 727-733
    |
    Published online on: May 23, 2011
       https://doi.org/10.3892/ijo.2011.1049
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Abstract

The development of resistance to cisplatin during treatment of bladder cancer constitutes a major obstacle to curing bladder cancer. The identification of epigenetic biomarker molecules for cisplatin resistance and the elucidation of the function of the identified genes in bladder cancer will provide useful information. We found that the candidate gene TLX3 was unmethylated in cisplatin sensitive cells and methylated in resistant cells. The suppression of TLX3 expression using TLX3-specific shRNA in parental cells increased cisplatin resistance. Contrarily, overexpression of TLX3 in resistant cells induced increased sensitivity to cisplatin. We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test. Cisplatin sensitivity was closely associated with the methylation status of TLX3. These findings showed that the TLX3 methylation may be useful as a novel biomarker for cisplatin resistance and can be used to design therapies to counteract the resistance against cisplatin in bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tada Y, Yokomizo A, Shiota M, Tsunoda T, Plass C and Naito S: Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer. Int J Oncol 39: 727-733, 2011.
APA
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., & Naito, S. (2011). Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer. International Journal of Oncology, 39, 727-733. https://doi.org/10.3892/ijo.2011.1049
MLA
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., Naito, S."Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer". International Journal of Oncology 39.3 (2011): 727-733.
Chicago
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., Naito, S."Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer". International Journal of Oncology 39, no. 3 (2011): 727-733. https://doi.org/10.3892/ijo.2011.1049
Copy and paste a formatted citation
x
Spandidos Publications style
Tada Y, Yokomizo A, Shiota M, Tsunoda T, Plass C and Naito S: Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer. Int J Oncol 39: 727-733, 2011.
APA
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., & Naito, S. (2011). Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer. International Journal of Oncology, 39, 727-733. https://doi.org/10.3892/ijo.2011.1049
MLA
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., Naito, S."Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer". International Journal of Oncology 39.3 (2011): 727-733.
Chicago
Tada, Y., Yokomizo, A., Shiota, M., Tsunoda, T., Plass, C., Naito, S."Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer". International Journal of Oncology 39, no. 3 (2011): 727-733. https://doi.org/10.3892/ijo.2011.1049
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