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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2011 Volume 39 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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October 2011 Volume 39 Issue 4

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Article Open Access

Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma

  • Authors:
    • Keisuke Sugahara
    • Yuichi Michikawa
    • Kenichi Ishikawa
    • Yoshimi Shoji
    • Mayumi Iwakawa
    • Takahiko Shibahara
    • Takashi Imai

  • View Affiliations / Copyright

    Affiliations: RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263-8555, Japan, RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Anagawa, Inage, Chiba 263-8555, Japan
  • Pages: 761-769
    |
    Published online on: June 22, 2011
       https://doi.org/10.3892/ijo.2011.1094
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Abstract

Lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) is known to associate with a significant decrease of 5-year survival. Genetic factors related to the difference of the LNM status in the OSCC have been not fully elucidated. Array-based comparative genomic hybridization (CGH) with individual gene-level resolution and real-time quantitative polymerase chain reaction (QPCR) were conducted using primary tumor materials resected from 54 OSCC patients with (n=22) or without (n=32) cervical LNM. Frequent gain was observed at the 11q13 region exclusively in patients with cervical LNM, which was confirmed by real-time QPCR experiments using 11 genes (TPCN2, MYEOV, CCND1, ORAOV1, FGF4, TMEM16A, FADD, PPFIA1, CTTN, SHANK2 and DHCR7) in this region. It was revealed that two distinct amplification cores existed, which were separated by a breakpoint between MYEOV and CCND1 in the 11q13 region. The combination of copy number amplification at CTTN (core 2) and/or TPCN2/MYEOV (core 1), selected from each core, was most significantly associated with cervical LNM (P=0.0035). Two amplification cores at the 11q13 region may have biological impacts on OSCC cells to spread from the primary site to local lymph nodes. Further study of a larger patient series should be conducted to validate these results.

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Copy and paste a formatted citation
Spandidos Publications style
Sugahara K, Michikawa Y, Ishikawa K, Shoji Y, Iwakawa M, Shibahara T and Imai T: Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma. Int J Oncol 39: 761-769, 2011.
APA
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., & Imai, T. (2011). Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma. International Journal of Oncology, 39, 761-769. https://doi.org/10.3892/ijo.2011.1094
MLA
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., Imai, T."Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma". International Journal of Oncology 39.4 (2011): 761-769.
Chicago
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., Imai, T."Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma". International Journal of Oncology 39, no. 4 (2011): 761-769. https://doi.org/10.3892/ijo.2011.1094
Copy and paste a formatted citation
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Spandidos Publications style
Sugahara K, Michikawa Y, Ishikawa K, Shoji Y, Iwakawa M, Shibahara T and Imai T: Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma. Int J Oncol 39: 761-769, 2011.
APA
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., & Imai, T. (2011). Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma. International Journal of Oncology, 39, 761-769. https://doi.org/10.3892/ijo.2011.1094
MLA
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., Imai, T."Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma". International Journal of Oncology 39.4 (2011): 761-769.
Chicago
Sugahara, K., Michikawa, Y., Ishikawa, K., Shoji, Y., Iwakawa, M., Shibahara, T., Imai, T."Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma". International Journal of Oncology 39, no. 4 (2011): 761-769. https://doi.org/10.3892/ijo.2011.1094
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