THYMIDINE KINASE IS EXPRESSED DIFFERENTLY IN TRANSFORMED VERSUS NORMAL-CELLS - A NOVEL TEST FOR MALIGNANCY

  • Authors:
    • M HENGSTSCHLAGER
    • EW MULLNER
    • E WAWRA
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  • Published online on: January 1, 1994     https://doi.org/10.3892/ijo.4.1.207
  • Pages: 207-210
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Abstract

Using a cytofluorometric assay, we studied the time course of thymidine kinase activity during the cell-cycle in logarithmically growing cells. Two different patterns were found. Many cells, including all strains of normal diploid fibroblasts, exhibited a transient stimulation of enzyme activity during early S-phase. On the contrary, virally transformed cells or lines derived from tumors also increased enzyme activity during G1/S, but kept this level until mitosis. In the latter case, the absolute enzyme activity was significantly higher during all phases of the cell-cycle than in normal cells. Beside its importance for the understanding of the transformed state, this phenomenon has obvious benefits for tumor diagnosis.

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January 1994
Volume 4 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
HENGSTSCHLAGER M, MULLNER E and WAWRA E: THYMIDINE KINASE IS EXPRESSED DIFFERENTLY IN TRANSFORMED VERSUS NORMAL-CELLS - A NOVEL TEST FOR MALIGNANCY. Int J Oncol 4: 207-210, 1994.
APA
HENGSTSCHLAGER, M., MULLNER, E., & WAWRA, E. (1994). THYMIDINE KINASE IS EXPRESSED DIFFERENTLY IN TRANSFORMED VERSUS NORMAL-CELLS - A NOVEL TEST FOR MALIGNANCY. International Journal of Oncology, 4, 207-210. https://doi.org/10.3892/ijo.4.1.207
MLA
HENGSTSCHLAGER, M., MULLNER, E., WAWRA, E."THYMIDINE KINASE IS EXPRESSED DIFFERENTLY IN TRANSFORMED VERSUS NORMAL-CELLS - A NOVEL TEST FOR MALIGNANCY". International Journal of Oncology 4.1 (1994): 207-210.
Chicago
HENGSTSCHLAGER, M., MULLNER, E., WAWRA, E."THYMIDINE KINASE IS EXPRESSED DIFFERENTLY IN TRANSFORMED VERSUS NORMAL-CELLS - A NOVEL TEST FOR MALIGNANCY". International Journal of Oncology 4, no. 1 (1994): 207-210. https://doi.org/10.3892/ijo.4.1.207