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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1994 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1994 Volume 4 Issue 2

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IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA

  • Authors:
    • GJ CHANDRAN
    • P BALARAM
    • S KANNAN
    • MR PILLAI
    • KR NALINAKUMARI
    • MK NAIR

  • View Affiliations / Copyright

    Affiliations: REG CANC CTR,DIV DENT SURG,THIRUVANANTHAPURAM,KERALA,INDIA. REG CANC CTR,DIV RADIAT ONCOL,THIRUVANANTHAPURAM,KERALA,INDIA.
  • Pages: 503-508
    |
    Published online on: February 1, 1994
       https://doi.org/10.3892/ijo.4.2.503
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Abstract

An important growth factor involved in epithelial carcinogenesis is the epidermal growth factor (EGF). The present study analyze the expression pattern of EGF and its receptor (EGFR) in different stages of tumour progression in oral mucosa (normal epithelium, non-dysplastic and dysplastic leukoplakias and carcinomas). Alterations in expression pattern of EGFR was not significant in the various tissues from normal mucosa to malignancy. In all these stages EGFR positivity was confined to the immature basal or basaloid cells. EGF however showed marked alterations in expression in different stages of tumour progression in oral mucosa. Most of the malignant cells were positive for EGF antibodies while, only a few lower layers of cells were stained in normal mucosa and in dysplastic leukoplakia lesions, more number of cells expressed EGF than normal tissue. The present study thus shows the autocrine role of the EGF and EGFR and the possibility of using EGF as a marker for tumour progression in oral mucosa.

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Copy and paste a formatted citation
Spandidos Publications style
CHANDRAN G, BALARAM P, KANNAN S, PILLAI M, NALINAKUMARI K and NAIR M: IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA. Int J Oncol 4: 503-508, 1994.
APA
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., & NAIR, M. (1994). IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA. International Journal of Oncology, 4, 503-508. https://doi.org/10.3892/ijo.4.2.503
MLA
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., NAIR, M."IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA". International Journal of Oncology 4.2 (1994): 503-508.
Chicago
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., NAIR, M."IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA". International Journal of Oncology 4, no. 2 (1994): 503-508. https://doi.org/10.3892/ijo.4.2.503
Copy and paste a formatted citation
x
Spandidos Publications style
CHANDRAN G, BALARAM P, KANNAN S, PILLAI M, NALINAKUMARI K and NAIR M: IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA. Int J Oncol 4: 503-508, 1994.
APA
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., & NAIR, M. (1994). IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA. International Journal of Oncology, 4, 503-508. https://doi.org/10.3892/ijo.4.2.503
MLA
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., NAIR, M."IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA". International Journal of Oncology 4.2 (1994): 503-508.
Chicago
CHANDRAN, G., BALARAM, P., KANNAN, S., PILLAI, M., NALINAKUMARI, K., NAIR, M."IMMUNOHISTOCHEMICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR AND ITS RECEPTOR IN NORMAL, PREMALIGNANT AND MALIGNANT ORAL-MUCOSA". International Journal of Oncology 4, no. 2 (1994): 503-508. https://doi.org/10.3892/ijo.4.2.503
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