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TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES

  • Authors:
    • LM WITTERS
    • H ALMONDHIRY
    • YL MATTHEWS
    • RP WALKER
    • BC LANGTON
    • JR DASCH
    • A LIPTON

  • View Affiliations

  • Published online on: April 1, 1994     https://doi.org/10.3892/ijo.4.4.943
  • Pages: 943-950
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Abstract

Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.

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April 1994
Volume 4 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
WITTERS L, ALMONDHIRY H, MATTHEWS Y, WALKER R, LANGTON B, DASCH J and LIPTON A: TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES. Int J Oncol 4: 943-950, 1994
APA
WITTERS, L., ALMONDHIRY, H., MATTHEWS, Y., WALKER, R., LANGTON, B., DASCH, J., & LIPTON, A. (1994). TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES. International Journal of Oncology, 4, 943-950. https://doi.org/10.3892/ijo.4.4.943
MLA
WITTERS, L., ALMONDHIRY, H., MATTHEWS, Y., WALKER, R., LANGTON, B., DASCH, J., LIPTON, A."TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES". International Journal of Oncology 4.4 (1994): 943-950.
Chicago
WITTERS, L., ALMONDHIRY, H., MATTHEWS, Y., WALKER, R., LANGTON, B., DASCH, J., LIPTON, A."TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES". International Journal of Oncology 4, no. 4 (1994): 943-950. https://doi.org/10.3892/ijo.4.4.943