P-GLYCOPROTEIN EXPRESSION IN NON-HODGKINS-LYMPHOMA

  • Authors:
    • R WEST
    • E BOYLE
    • D GRIGNON
    • I CHIN-YEE
  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1237
  • Pages: 1237-1242
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Abstract

Tissues from twenty-nine patients with non-Hodgkin's lymphoma (NHL) were examined for the presence of the P-glycoprotein (Pgp), a transmembrane protein associated with multidrug resistance. Six of the 29 NHL (21%) expressed Pgp; 3 of 8 (38%) low grade and 3 of 16 (19%) intermediate grade. No relationship was found between Pgp expression and age, stage, lactate dehydrogenase levels, extranodal disease or previous chemotherapy exposure. Pgp was present in 3 of 13 (23%) complete responders and 3 of 11 (27%) partial or nonresponders (p>0.10) suggesting no direct association between treatment response and Pgp expression in this series.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
WEST R, BOYLE E, GRIGNON D and CHIN-YEE I: P-GLYCOPROTEIN EXPRESSION IN NON-HODGKINS-LYMPHOMA. Int J Oncol 4: 1237-1242, 1994.
APA
WEST, R., BOYLE, E., GRIGNON, D., & CHIN-YEE, I. (1994). P-GLYCOPROTEIN EXPRESSION IN NON-HODGKINS-LYMPHOMA. International Journal of Oncology, 4, 1237-1242. https://doi.org/10.3892/ijo.4.6.1237
MLA
WEST, R., BOYLE, E., GRIGNON, D., CHIN-YEE, I."P-GLYCOPROTEIN EXPRESSION IN NON-HODGKINS-LYMPHOMA". International Journal of Oncology 4.6 (1994): 1237-1242.
Chicago
WEST, R., BOYLE, E., GRIGNON, D., CHIN-YEE, I."P-GLYCOPROTEIN EXPRESSION IN NON-HODGKINS-LYMPHOMA". International Journal of Oncology 4, no. 6 (1994): 1237-1242. https://doi.org/10.3892/ijo.4.6.1237