RECOVERY OF SENSITIVITY TO CISPLATINUM AND EPIDOXORUBICIN BY IONIDAMINE AND INTERFERON IN ADVANCED OVARIAN-CANCER

  • Authors:
    • RV IAFFAIOLI
    • A TORTORIELLO
    • G FACCHINI
    • F CAPONIGRO
    • P MASTRANTONIO
    • ML BARZELLONI
    • G GESUE
    • G MANTOVANI
    • M SANTANGELO
  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1265
  • Pages: 1265-1269
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Abstract

Eighteen patients with advanced ovarian cancer not or no longer responding to cisplatinum and epidoxorubicin including combination chemotherapy were retreated with the above two drugs in combination with lonidamine and interferon, administered with the aim of restoring chemosensitivity. Overall response rate was 32%, with one durable complete response and four partial responses. Toxicity was quite manageable, myalgia being the main additional toxic effect with respect to those reported with conventional chemotherapy. Our study emphasizes the need for additional trials with agents able to overcome drug resistance, which is the chief determinant of treatment failure in advanced ovarian cancer.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
IAFFAIOLI R, TORTORIELLO A, FACCHINI G, CAPONIGRO F, MASTRANTONIO P, BARZELLONI M, GESUE G, MANTOVANI G and SANTANGELO M: RECOVERY OF SENSITIVITY TO CISPLATINUM AND EPIDOXORUBICIN BY IONIDAMINE AND INTERFERON IN ADVANCED OVARIAN-CANCER. Int J Oncol 4: 1265-1269, 1994
APA
IAFFAIOLI, R., TORTORIELLO, A., FACCHINI, G., CAPONIGRO, F., MASTRANTONIO, P., BARZELLONI, M. ... SANTANGELO, M. (1994). RECOVERY OF SENSITIVITY TO CISPLATINUM AND EPIDOXORUBICIN BY IONIDAMINE AND INTERFERON IN ADVANCED OVARIAN-CANCER. International Journal of Oncology, 4, 1265-1269. https://doi.org/10.3892/ijo.4.6.1265
MLA
IAFFAIOLI, R., TORTORIELLO, A., FACCHINI, G., CAPONIGRO, F., MASTRANTONIO, P., BARZELLONI, M., GESUE, G., MANTOVANI, G., SANTANGELO, M."RECOVERY OF SENSITIVITY TO CISPLATINUM AND EPIDOXORUBICIN BY IONIDAMINE AND INTERFERON IN ADVANCED OVARIAN-CANCER". International Journal of Oncology 4.6 (1994): 1265-1269.
Chicago
IAFFAIOLI, R., TORTORIELLO, A., FACCHINI, G., CAPONIGRO, F., MASTRANTONIO, P., BARZELLONI, M., GESUE, G., MANTOVANI, G., SANTANGELO, M."RECOVERY OF SENSITIVITY TO CISPLATINUM AND EPIDOXORUBICIN BY IONIDAMINE AND INTERFERON IN ADVANCED OVARIAN-CANCER". International Journal of Oncology 4, no. 6 (1994): 1265-1269. https://doi.org/10.3892/ijo.4.6.1265