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BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES

  • Authors:
    • A REPHAELI
    • J NORDENBERG
    • A AVIRAM
    • E RABIZADEH
    • Y ZIMRA
    • A NUDELMAN
    • A NOVOGRODSKY
    • M SHAKLAI

  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1387
  • Pages: 1387-1391
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

A study of the effects of three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation and differentiation of primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA was an effective inhibitor of cell proliferation and inducer of cytodifferentiation. An acute non-lymphoblastic leukemia patient was treated with sodium butyrate. A temporary increase in differentiation-associated parameters were noted. However, the effects of SB were short-lived. The lack of clinical response led to the development of a BA prodrug pivaloyloxymethylbutyrate (AN-9). This prodrug was more potent in vitro than BA in the induction of cytodifferentiation and inhibition of cell proliferation.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • CiteScore: 11.4
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  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
REPHAELI A, NORDENBERG J, AVIRAM A, RABIZADEH E, ZIMRA Y, NUDELMAN A, NOVOGRODSKY A and SHAKLAI M: BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES. Int J Oncol 4: 1387-1391, 1994
APA
REPHAELI, A., NORDENBERG, J., AVIRAM, A., RABIZADEH, E., ZIMRA, Y., NUDELMAN, A. ... SHAKLAI, M. (1994). BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES. International Journal of Oncology, 4, 1387-1391. https://doi.org/10.3892/ijo.4.6.1387
MLA
REPHAELI, A., NORDENBERG, J., AVIRAM, A., RABIZADEH, E., ZIMRA, Y., NUDELMAN, A., NOVOGRODSKY, A., SHAKLAI, M."BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES". International Journal of Oncology 4.6 (1994): 1387-1391.
Chicago
REPHAELI, A., NORDENBERG, J., AVIRAM, A., RABIZADEH, E., ZIMRA, Y., NUDELMAN, A., NOVOGRODSKY, A., SHAKLAI, M."BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES". International Journal of Oncology 4, no. 6 (1994): 1387-1391. https://doi.org/10.3892/ijo.4.6.1387