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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2012 Volume 40 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2012 Volume 40 Issue 2

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Article

Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer

  • Authors:
    • Fengming Lan
    • Xiao Yue
    • Lei Han
    • Zhendong Shi
    • Yang Yang
    • Peiyu Pu
    • Zhi Yao
    • Chunsheng Kang

  • View Affiliations / Copyright

    Affiliations: Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, P.R. China, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, 152 Anshan Road, Heping, Tianjin 300052, P.R. China
  • Pages: 519-526
    |
    Published online on: September 28, 2011
       https://doi.org/10.3892/ijo.2011.1215
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Abstract

Transcription factor 7 like 2 (TCF7L2, also known as TCF4) is a Wnt signaling pathway transcription factor involved in regulation of numerous Wnt targeted genes. Recently, thousands of high-confidence TCF4 binding sites were reported in LS174T colon carcinoma cells, however, potential TCF4 target miRNAs remain largely unknown. Here, we utilized a bioinformatics approach to discover 26 miRNA transcription start sites (TSSs) within close proximity to TCF4 chromatin occupancy sites, and validated these sites as bona fide TCF4 targets in LS174T colon carcinoma cells, MCF-7 breast cancer cells and U87 glioma cells by ChIP-PCR. We then selected miR-21 to demonstrate for the first time direct TCF4 transcriptional activation of a miRNA via binding to the promoter region. Tissue array analysis supported this finding, revealing a positive correlation between activation of the β-catenin pathway and in situ expression of miR-21. Finally, based upon the well known but poorly understood preventive effect of aspirin on colorectal cancer incidence and mortality, we report downregulation of miR-21 upon administration of aspirin. In sum, our findings identify direct transcriptional regulation of miR-21 by TCF4 and suggest a role for miR-21 in cancer cell proliferation and invasion upon activation of β-catenin/TCF4 signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Lan F, Yue X, Han L, Shi Z, Yang Y, Pu P, Yao Z and Kang C: Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. Int J Oncol 40: 519-526, 2012.
APA
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P. ... Kang, C. (2012). Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. International Journal of Oncology, 40, 519-526. https://doi.org/10.3892/ijo.2011.1215
MLA
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P., Yao, Z., Kang, C."Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer". International Journal of Oncology 40.2 (2012): 519-526.
Chicago
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P., Yao, Z., Kang, C."Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer". International Journal of Oncology 40, no. 2 (2012): 519-526. https://doi.org/10.3892/ijo.2011.1215
Copy and paste a formatted citation
x
Spandidos Publications style
Lan F, Yue X, Han L, Shi Z, Yang Y, Pu P, Yao Z and Kang C: Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. Int J Oncol 40: 519-526, 2012.
APA
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P. ... Kang, C. (2012). Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer. International Journal of Oncology, 40, 519-526. https://doi.org/10.3892/ijo.2011.1215
MLA
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P., Yao, Z., Kang, C."Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer". International Journal of Oncology 40.2 (2012): 519-526.
Chicago
Lan, F., Yue, X., Han, L., Shi, Z., Yang, Y., Pu, P., Yao, Z., Kang, C."Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer". International Journal of Oncology 40, no. 2 (2012): 519-526. https://doi.org/10.3892/ijo.2011.1215
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