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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2012 Volume 41 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 41 Issue 1

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Review

The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)

  • Authors:
    • Uwe A. Wittel
    • Navneet Momi
    • Gabriel Seifert
    • Thorsten Wiech
    • Ulrich T. Hopt
    • Surinder K. Batra

  • View Affiliations / Copyright

    Affiliations: Department of General- and Visceral Surgery, Universitätsklinik Freiburg, Freiburg, Germany, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA, Institute of Pathology, Universitätsklinik Freiburg, Freiburg, Germany
  • Pages: 5-14
    |
    Published online on: March 23, 2012
       https://doi.org/10.3892/ijo.2012.1414
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Abstract

Despite extensive efforts, pancreatic cancer remains incurable. Most risk factors, such as genetic disposition, metabolic diseases or chronic pancreatitis cannot be influenced. By contrast, cigarette smoking, an important risk factor for pancreatic cancer, can be controlled. Despite the epidemiological evidence of the detrimental effects of cigarette smoking with regard to pancreatic cancer development and its unique property of being influenceable, our understanding of cigarette smoke-induced pancreatic carcinogenesis is limited. Current data on cigarette smoke-induced pancreatic carcinogenesis indicate multifactorial events that are triggered by nicotine, which is the major pharmacologically active constituent of tobacco smoke. In addition to nicotine, a vast number of carcinogens have the potential to reach the pancreatic gland, where they are metabolized, in some instances to even more toxic compounds. These metabolic events are not restricted to pancreatic ductal cells. Several studies show that acinar cells are also greatly affected. Furthermore, pancreatic cancer progenitor cells do not only derive from the ductal epithelial lineage, but also from acinar cells. This sheds new light on cigarette smoke-induced acinar cell damage. On this background, our objective is to outline a multifactorial model of tobacco smoke-induced pancreatic carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Wittel UA, Momi N, Seifert G, Wiech T, Hopt UT and Batra SK: The pathobiological impact of cigarette smoke on pancreatic cancer development (Review). Int J Oncol 41: 5-14, 2012.
APA
Wittel, U.A., Momi, N., Seifert, G., Wiech, T., Hopt, U.T., & Batra, S.K. (2012). The pathobiological impact of cigarette smoke on pancreatic cancer development (Review). International Journal of Oncology, 41, 5-14. https://doi.org/10.3892/ijo.2012.1414
MLA
Wittel, U. A., Momi, N., Seifert, G., Wiech, T., Hopt, U. T., Batra, S. K."The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)". International Journal of Oncology 41.1 (2012): 5-14.
Chicago
Wittel, U. A., Momi, N., Seifert, G., Wiech, T., Hopt, U. T., Batra, S. K."The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)". International Journal of Oncology 41, no. 1 (2012): 5-14. https://doi.org/10.3892/ijo.2012.1414
Copy and paste a formatted citation
x
Spandidos Publications style
Wittel UA, Momi N, Seifert G, Wiech T, Hopt UT and Batra SK: The pathobiological impact of cigarette smoke on pancreatic cancer development (Review). Int J Oncol 41: 5-14, 2012.
APA
Wittel, U.A., Momi, N., Seifert, G., Wiech, T., Hopt, U.T., & Batra, S.K. (2012). The pathobiological impact of cigarette smoke on pancreatic cancer development (Review). International Journal of Oncology, 41, 5-14. https://doi.org/10.3892/ijo.2012.1414
MLA
Wittel, U. A., Momi, N., Seifert, G., Wiech, T., Hopt, U. T., Batra, S. K."The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)". International Journal of Oncology 41.1 (2012): 5-14.
Chicago
Wittel, U. A., Momi, N., Seifert, G., Wiech, T., Hopt, U. T., Batra, S. K."The pathobiological impact of cigarette smoke on pancreatic cancer development (Review)". International Journal of Oncology 41, no. 1 (2012): 5-14. https://doi.org/10.3892/ijo.2012.1414
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