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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2013 Volume 43 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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August 2013 Volume 43 Issue 2

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Article

Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer

  • Authors:
    • Witold Szaflarski
    • Patrycja Sujka-Kordowska
    • Bartosz Pula
    • Karolina Jaszczyńska-Nowinka
    • Małgorzata Andrzejewska
    • Piotr Zawierucha
    • Piotr Dziegiel
    • Michał Nowicki
    • Pavel Ivanov
    • Maciej Zabel

  • View Affiliations / Copyright

    Affiliations: Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznań, Poland, Department of Histology and Embryology, Wrocław Medical University, 50-368 Wrocław, Poland, Department of Gynaecological Oncology, Poznan University of Medical Sciences, 60-569 Poznań, Poland, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
  • Pages: 513-520
    |
    Published online on: June 5, 2013
       https://doi.org/10.3892/ijo.2013.1975
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Abstract

Vaults are cytoplasmic ribonucleoprotein particles composed of three proteins (MVP, TEP1, vPARP) and vault‑associated RNAs (vRNAs). Although the cellular functions of vaults remain unclear, vaults are strongly linked to the development of multidrug resistance (MDR), the major obstacle to the efficient treatment of cancers. Available published data suggest that vaults and their components are frequently upregulated in broad variety of multidrug-resistant cancer cell lines and tumors of different histological origin. Here, we provide detailed analysis of vault protein expression in post-surgery ovarian cancer samples from patients that were not exposed to chemotherapy. Our analysis suggests that vault proteins are expressed in the ovaries of healthy individuals but their expression in cancer patients is changed. Specifically, MVP, TEP1 and vPARP mRNA levels are significantly decreased in cancer samples with tendency of lower expression in higher-grade tumors. The pattern of vault protein mRNA expression is strongly correlated with the expression of other MDR-associated proteins such as MDR1, MRP1 and BCRP. Surprisingly, the protein levels of MVP, TEP1 and vPARP are actually increased in the higher‑grade tumors suggesting existence of post-transcriptional regulation of vault component production.

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Copy and paste a formatted citation
Spandidos Publications style
Szaflarski W, Sujka-Kordowska P, Pula B, Jaszczyńska-Nowinka K, Andrzejewska M, Zawierucha P, Dziegiel P, Nowicki M, Ivanov P, Zabel M, Zabel M, et al: Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. Int J Oncol 43: 513-520, 2013.
APA
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P. ... Zabel, M. (2013). Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. International Journal of Oncology, 43, 513-520. https://doi.org/10.3892/ijo.2013.1975
MLA
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P., Dziegiel, P., Nowicki, M., Ivanov, P., Zabel, M."Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer". International Journal of Oncology 43.2 (2013): 513-520.
Chicago
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P., Dziegiel, P., Nowicki, M., Ivanov, P., Zabel, M."Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer". International Journal of Oncology 43, no. 2 (2013): 513-520. https://doi.org/10.3892/ijo.2013.1975
Copy and paste a formatted citation
x
Spandidos Publications style
Szaflarski W, Sujka-Kordowska P, Pula B, Jaszczyńska-Nowinka K, Andrzejewska M, Zawierucha P, Dziegiel P, Nowicki M, Ivanov P, Zabel M, Zabel M, et al: Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. Int J Oncol 43: 513-520, 2013.
APA
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P. ... Zabel, M. (2013). Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer. International Journal of Oncology, 43, 513-520. https://doi.org/10.3892/ijo.2013.1975
MLA
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P., Dziegiel, P., Nowicki, M., Ivanov, P., Zabel, M."Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer". International Journal of Oncology 43.2 (2013): 513-520.
Chicago
Szaflarski, W., Sujka-Kordowska, P., Pula, B., Jaszczyńska-Nowinka, K., Andrzejewska, M., Zawierucha, P., Dziegiel, P., Nowicki, M., Ivanov, P., Zabel, M."Expression profiles of vault components MVP, TEP1 and vPARP and their correlation to other multidrug resistance proteins in ovarian cancer". International Journal of Oncology 43, no. 2 (2013): 513-520. https://doi.org/10.3892/ijo.2013.1975
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