1.
|
IARC: World Cancer Report. IARC; Lyon:
2008
|
2.
|
INCA: Estimativa 2012: Incidência de
câncer no Brasil. INCA Rio de Janeiro; 2011, (In Portuguese).
|
3.
|
Castro N, Osório C, Torres C, et al:
Evidence that molecular changes in cells occur before morphological
alterations during the progression of breast ductal carcinoma.
Breast Cancer Res. 10:R872008. View Article : Google Scholar
|
4.
|
Tamimi R, Baer H, Marotti J, et al:
Comparison of molecular phenotypes of ductal carcinoma in situ and
invasive breast cancer. Breast Cancer Res. 10:R672008. View Article : Google Scholar : PubMed/NCBI
|
5.
|
Sjöblom T, Jones S, Wood L, et al: The
consensus coding sequences of human breast and colorectal cancers.
Science. 314:268–274. 2006.
|
6.
|
Deng L-W, Chiu I and Strominger J: MLL 5
protein forms intra-nuclear foci and overexpression inhibits cell
cycle progression. Proc Natl Acad Sci USA. 101:757–762. 2004.
View Article : Google Scholar : PubMed/NCBI
|
7.
|
Ayton P and Cleary M: Molecular mechanisms
of leukemogenesis mediated by MLL fusion proteins. Oncogene.
20:5695–5707. 2001. View Article : Google Scholar : PubMed/NCBI
|
8.
|
Yu B, Hess J, Horning S, Brown G and
Korsmeyer S: Altered Hox expression and segmental identity in
Mll-mutant mice. Nature. 378:505–508. 1995. View Article : Google Scholar : PubMed/NCBI
|
9.
|
McKinnell I, Ishibashi J, Le Grand F, et
al: Pax7 activates myogenic genes by recruitment of a histone
methyltransferase complex. Nat Cell Biol. 10:77–84. 2008.
View Article : Google Scholar : PubMed/NCBI
|
10.
|
Aziz A, Liu Q-C and Dilworth F: Regulating
a master regulator: establishing tissue-specific gene expression in
skeletal muscle. Epigenetics. 5:691–695. 2010. View Article : Google Scholar : PubMed/NCBI
|
11.
|
Ruault M, Brun M, Ventura M, Roizès G and
De Sario A: MLL3, a new human member of the TRX/MLL gene family,
maps to 7q36, a chromosome region frequently deleted in myeloid
leukaemia. Gene. 284:73–81. 2002. View Article : Google Scholar : PubMed/NCBI
|
12.
|
Lee J, Kim D-H, Lee S, et al: A tumor
suppressive coactivator complex of p53 containing ASC-2 and histone
H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl
Acad Sci USA. 106:8513–8518. 2009. View Article : Google Scholar : PubMed/NCBI
|
13.
|
Glaser S, Schaft J, Lubitz S, et al:
Multiple epigenetic maintenance factors implicated by the loss of
Mll2 in mouse development. Development. 133:1423–1432. 2006.
View Article : Google Scholar : PubMed/NCBI
|
14.
|
Emerling B, Bonifas J, Kratz C, et al:
MLL5, a homolog of Drosophila trithorax located within a
segment of chromosome band 7q22 implicated in myeloid leukemia.
Oncogene. 21:4849–4854. 2002.PubMed/NCBI
|
15.
|
Sebastian S, Sreenivas P, Sambasivan R, et
al: MLL5, a trithorax homolog, indirectly regulates H3K4
methylation, represses cyclin A2 expression and promotes myogenic
differentiation. Proc Natl Acad Sci USA. 106:4719–4724. 2009.
View Article : Google Scholar
|
16.
|
Madan V, Madan B, Brykczynska U, et al:
Impaired function of primitive hematopoietic cells in mice lacking
the Mixed-Lineage-Leukemia homolog MLL5. Blood. 113:1444–1454.
2009. View Article : Google Scholar : PubMed/NCBI
|
17.
|
Ansari K, Kasiri S, Hussain I and Mandal
S: Mixed lineage leukemia histone methylases play critical roles in
estrogen-mediated regulation of HOXC13. FEBS J. 276:7400–7411.
2009. View Article : Google Scholar : PubMed/NCBI
|
18.
|
Mo R, Rao S and Zhu Y-J: Identification of
the MLL2 complex as a coactivator for estrogen receptor alpha. J
Biol Chem. 281:15714–15720. 2006. View Article : Google Scholar : PubMed/NCBI
|
19.
|
Ansari K, Hussain I, Kasiri S and Mandal
S: HOXC10 is overexpressed in breast cancer and transcriptionally
regulated by estrogen via involvement of histone methylases MLL3
and MLL4. J Mol Endocrinol. 48:61–75. 2012. View Article : Google Scholar : PubMed/NCBI
|
20.
|
Neve R, Chin K, Fridlyand J, et al: A
collection of breast cancer cell lines for the study of
functionally distinct cancer subtypes. Cancer Cell. 10:515–527.
2006. View Article : Google Scholar : PubMed/NCBI
|
21.
|
Finak G, Bertos N, Pepin F, et al: Stromal
gene expression predicts clinical outcome in breast cancer. Nat
Med. 14:518–527. 2008. View
Article : Google Scholar : PubMed/NCBI
|
22.
|
Karnoub AE, Dash AB, Vo AP, et al:
Mesenchymal stem cells within tumour stroma promote breast cancer
metastasis. Nature. 449:557–563. 2007. View Article : Google Scholar : PubMed/NCBI
|
23.
|
Sims R, Nishioka K and Reinberg D: Histone
lysine methylation: a signature for chromatin function. Trends
Genet. 19:629–639. 2003. View Article : Google Scholar : PubMed/NCBI
|
24.
|
Miremadi A, Oestergaard M, Pharoah P and
Caldas C: Cancer genetics of epigenetic genes. Hum Mol Genet.
16:R28–R49. 2007. View Article : Google Scholar
|
25.
|
Hamamoto R, Silva F, Tsuge M, et al:
Enhanced SMYD3 expression is essential for the growth of breast
cancer cells. Cancer Sci. 97:113–118. 2006. View Article : Google Scholar : PubMed/NCBI
|
26.
|
Chang CJ and Hung MC: The role of EZH2 in
tumour progression. Br J Cancer. 106:243–247. 2012. View Article : Google Scholar : PubMed/NCBI
|
27.
|
Al Sarakbi W, Sasi W, Jiang W, Roberts T,
Newbold R and Mokbel K: The mRNA expression of SETD2 in human
breast cancer: correlation with clinicopathological parameters. BMC
Cancer. 9:2902009.PubMed/NCBI
|
28.
|
Nishikawa N, Toyota M, Suzuki H, et al:
Gene amplification and overexpression of PRDM14 in breast cancers.
Cancer Res. 67:9649–9657. 2007. View Article : Google Scholar : PubMed/NCBI
|
29.
|
Canaani E, Nakamura T, Rozovskaia T, et
al: ALL-1/MLL1, a homologue of Drosophila trithorax,
modifies chromatin and is directly involved in infant acute
leukaemia. Br J Cancer. 90:756–760. 2004.
|
30.
|
Patani N, Jiang W, Newbold R and Mokbel K:
Histone-modifier gene expression profiles are associated with
pathological and clinical outcomes in human breast cancer.
Anticancer Res. 31:4115–4125. 2011.PubMed/NCBI
|
31.
|
Liu H, Takeda S, Kumar R, et al:
Phosphorylation of MLL by ATR is required for execution of
mammalian S-phase checkpoint. Nature. 467:343–346. 2010. View Article : Google Scholar : PubMed/NCBI
|
32.
|
Huntsman D, Chin S, Muleris M, et al:
MLL2, the second human homolog of the Drosophila trithorax gene,
maps to 19q13.1 and is amplified in solid tumor cell lines.
Oncogene. 18:7975–7984. 1999. View Article : Google Scholar : PubMed/NCBI
|
33.
|
Morin RD, Mendez-Lago M, Mungall AJ, et
al: Frequent mutation of histone-modifying genes in non-Hodgkin
lymphoma. Nature. 476:298–303. 2011. View Article : Google Scholar : PubMed/NCBI
|
34.
|
Pasqualucci L, Trifonov V, Fabbri G, et
al: Analysis of the coding genome of diffuse large B-cell lymphoma.
Nat Genet. 43:830–837. 2011. View
Article : Google Scholar : PubMed/NCBI
|
35.
|
Dalgliesh G, Furge K, Greenman C, et al:
Systematic sequencing of renal carcinoma reveals inactivation of
histone modifying genes. Nature. 463:360–363. 2010. View Article : Google Scholar : PubMed/NCBI
|
36.
|
Guo C, Chang CC, Wortham M, et al: Global
identification of MLL2-targeted loci reveals MLL2’s role in diverse
signaling pathways. Proc Natl Acad Sci USA. 109:17603–17608.
2012.PubMed/NCBI
|
37.
|
Wang X-X, Fu L, Li X, et al: Somatic
mutations of the mixed-lineage leukemia 3 (MLL3) gene in primary
breast cancers. Pathol Oncol Res. 17:429–433. 2011. View Article : Google Scholar : PubMed/NCBI
|
38.
|
Parsons D, Li M, Zhang X, et al: The
genetic landscape of the childhood cancer medulloblastoma. Science.
331:435–439. 2011. View Article : Google Scholar : PubMed/NCBI
|
39.
|
Watanabe Y, Castoro R, Kim H, et al:
Frequent alteration of MLL3 frameshift mutations in microsatellite
deficient colorectal cancer. PLoS One. 6:e233202011. View Article : Google Scholar : PubMed/NCBI
|
40.
|
Damm F, Oberacker T, Thol F, et al:
Prognostic importance of histone methyltransferase MLL5 expression
in acute myeloid leukemia. J Clin Oncol. 29:682–689. 2011.
View Article : Google Scholar : PubMed/NCBI
|