Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma

  • Authors:
    • Yan Li
    • Xue Shi
    • Jingwen Zhang
    • Xiang Zhang
    • Robert C.G. Martin
  • View Affiliations

  • Published online on: November 21, 2013     https://doi.org/10.3892/ijo.2013.2184
  • Pages: 505-513
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Malignant transformation of hepatocellular carcinoma (HCC) occurs through repetitive liver injury in a context of inflammation and oxidative DNA damage. A spectrum of natural sesquiterpenoids from curcuma oil has displayed antioxidant, anti-inflammatory and anti-carcinogenic properties. The aim of the study was to investigate the hepatoprotective and anti-HCC effects of curcuma oil in vivo and in vitro. Mice were pretreated with curcuma oil (100 mg/kg) for 3 days, then treated with Concanavalin A (30 mg/kg). The hepatic tissue was evaluated for histology, CD4+ cell, interferon-γ, apoptosis, lipid peroxidation, 8-hydroxy-deoxyguanosine and MnSOD. C57L/J mice were treated with curcuma oil and 107 Hepa1-6 cells directly inoculated into liver lobes. The effects of curcuma oil on cell growth and cell death were evaluated. In addition, MnSOD, HSP60, catalase, NF-κB and caspase-3 were also investigated in the Hepa1-6 cells treated with curcuma oil. Pretreatment with curcuma oil significantly attenuates inflammation and oxidative damage by Concanavalin A. Treatment with curcuma oil can decrease the incidence of HCC. Curcuma oil inhibits cell growth and induces cell death in Hepa1-6 cells. Curcuma protected mice with hepatic injury from inflammatory and oxidative stress. Curcuma oil can inhibit hepatoma cell growth in vivo and in vitro.
View Figures
View References

Related Articles

Journal Cover

2014-February
Volume 44 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Shi X, Zhang J, Zhang X and Martin RC: Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma . Int J Oncol 44: 505-513, 2014.
APA
Li, Y., Shi, X., Zhang, J., Zhang, X., & Martin, R.C. (2014). Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma . International Journal of Oncology, 44, 505-513. https://doi.org/10.3892/ijo.2013.2184
MLA
Li, Y., Shi, X., Zhang, J., Zhang, X., Martin, R. C."Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma ". International Journal of Oncology 44.2 (2014): 505-513.
Chicago
Li, Y., Shi, X., Zhang, J., Zhang, X., Martin, R. C."Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma ". International Journal of Oncology 44, no. 2 (2014): 505-513. https://doi.org/10.3892/ijo.2013.2184