Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review)

  • Authors:
    • L. Lloyd Morgan
    • Anthony B. Miller
    • Annie Sasco
    • Devra Lee Davis
  • View Affiliations

  • Published online on: February 25, 2015     https://doi.org/10.3892/ijo.2015.2908
  • Pages: 1865-1871
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Abstract

Quickly changing technologies and intensive uses of radiofrequency electromagnetic field (RF-EMF)‑emitting phones pose a challenge to public health. Mobile phone users and uses and exposures to other wireless transmitting devices (WTDs) have increased in the past few years. We consider that CERENAT, a French national study, provides an important addition to the literature evaluating the use of mobile phones and risk of brain tumors. The CERENAT finding of increased risk of glioma is consistent with studies that evaluated use of mobile phones for a decade or longer and corroborate those that have shown a risk of meningioma from mobile phone use. In CERENAT, exposure to RF‑EMF from digitally enhanced cordless telephones (DECTs), used by over half the population of France during the period of this study, was not evaluated. If exposures to DECT phones could have been taken into account, the risks of glioma from mobile phone use in CERENAT are likely to be higher than published. We conclude that radiofrequency fields should be classified as a Group 2A ̔probable̓ human carcinogen under the criteria used by the International Agency for Research on Cancer (Lyon, France). Additional data should be gathered on exposures to mobile and cordless phones, other WTDs, mobile phone base stations and Wi‑Fi routers to evaluate their impact on public health. We advise that the as low as reasonable achievable (ALARA) principle be adopted for uses of this technology, while a major cross‑disciplinary effort is generated to train researchers in bioelectromagnetics and provide monitoring of potential health impacts of RF‑EMF.

References

1 

Auvinen A, Hietanen M, Luukkonen R and Koskela RS: Brain tumors and salivary gland cancers among cellular telephone users. Epidemiology. 13:356–359. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Christensen HC, Schüz J, Kosteljanetz M, Poulsen HS, Boice JD Jr, McLaughlin JK and Johansen C: Cellular telephones and risk for brain tumors: A population-based, incident case-control study. Neurology. 64:1189–1195. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Shapiro WR, Selker RG, Fine HA, Black PM, Loeffler JS and Linet MS: Cellular-telephone use and brain tumors. N Engl J Med. 344:79–86. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Muscat JE, Malkin MG, Thompson S, Shore RE, Stellman SD, McRee D, Neugut AI and Wynder EL: Handheld cellular telephone use and risk of brain cancer. JAMA. 284:3001–3007. 2000.Erratum in: JAMA 286: 1293, 2001. View Article : Google Scholar : PubMed/NCBI

5 

INTERPHONE Study Group. Brain tumour risk in relation to mobile telephone use: Results of the INTERPHONE international case-control study. Int J Epidemiol. 39:675–694. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Coureau G, Bouvier G, Lebailly P, et al: Mobile phone use and brain tumours in the CERENAT case-control study. Occup Environ Med. 71:514–522. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Moon IS, Kim BG, Kim J, Lee JD and Lee WS: Association between vestibular schwannomas and mobile phone use. Tumour Biol. 35:581–587. 2014. View Article : Google Scholar :

8 

Hardell L, Carlberg M, Söderqvist F and Mild KH: Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997–2003 and 2007–2009 and use of mobile and cordless phones. Int J Oncol. 43:1036–1044. 2013.PubMed/NCBI

9 

Carlberg M, Söderqvist F, Hansson Mild K and Hardell L: Meningioma patients diagnosed 2007–2009 and the association with use of mobile and cordless phones: A case-control study. Environ Health. 12:602013. View Article : Google Scholar

10 

Hardell L, Carlberg M and Hansson Mild K: Re-analysis of risk for glioma in relation to mobile telephone use: Comparison with the results of the Interphone international case-control study. Int J Epidemiol. 40:1126–1128. 2011. View Article : Google Scholar

11 

INTERPHONE Study Group. Acoustic neuroma risk in relation to mobile telephone use: Results of the INTERPHONE international case-control study. Cancer Epidemiol. 35:453–464. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Hardell L, Carlberg M, Söderqvist F and Mild KH: Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997–2003 and 2007–2009 and use of mobile and cordless phones. Int J Oncol. 43:1036–1044. 2013.PubMed/NCBI

13 

The World Bank. Mobile cellular subscriptions (per 100 people). http://data.worldbank.org/indicator/IT.CEL.SETS.P2?order=wbapi_data_value_2006wbapi_data_value&sort=asc&page=1urisimplehttp://data.worldbank.org/indicator/IT.CEL.SETS.P2?order=wbapi_data_value_2006wbapi_data_value&sort=asc&page=1. Accessed September 19, 2014

14 

Cardis E, Deltour I, Mann S, Moissonnier M, Taki M, Varsier N, Wake K and Wiart J: Distribution of RF energy emitted by mobile phones in anatomical structures of the brain. Phys Med Biol. 53:2771–2783. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Hardlell L and Carlberg M: Mobile phone and cordless phone use and the risk for glioma - Analysis of pooled case-control studies in Sweden, 1997–2003 and 2007–2009. Pathophysiology. Oct 29–2014.(Epub ahead of print).

16 

Hardell L and Carlberg M: Re: Mobile phone use and brain tumours in the CERENAT case-control study. Occup Environ Med. 72:792015. View Article : Google Scholar

17 

Coureau G, Leffondre K, Gruber A, Bouvier G and Baldi I: Author’s response: Re ‘Mobile phone use and brain tumours in the CERENAT case-control study’. Occup Environ Med. 72:79–80. 2015. View Article : Google Scholar

18 

Hardell L, Carlberg M and Hansson Mild K: Case-control study on cellular and cordless telephones and the risk for acoustic neuroma or meningioma in patients diagnosed 2000–2003. Neuroepidemiology. 25:120–128. 2005. View Article : Google Scholar

19 

International Agency for Research on Cancer (IARC). Non- ionizing radiation, part 2: radiofrequency electromagnetic fields. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. 102. IARC; Lyon: 2013

20 

Morgan LL, Kundi M and Carlberg M: Re-evaluation of the Interphone Study: Application of a correction factor. In: Proceedings of the Bioelectromagnetics Society Annual Meeting; Seoul, Korea. pp. 1–7. 2010

21 

Hardell L and Carlberg M: Using the Hill viewpoints from 1965 for evaluating strengths of evidence of the risk for brain tumors associated with use of mobile and cordless phones. Rev Environ Health. 28:97–106. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Hardell L and Carlberg M: Mobile phones, cordless phones and the risk for brain tumours. Int J Oncol. 35:5–17. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Hardell L, Carlberg M and Hansson Mild K: Pooled analysis of two case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997–2003. Int J Oncol. 28:509–518. 2006.PubMed/NCBI

24 

Aydin D, Feychting M, Schüz J, et al: Mobile phone use and brain tumors in children and adolescents: A multicenter case-control study. J Natl Cancer Inst. 103:1264–1276. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Deltour I, Auvinen A, Feychting M, Johansen C, Klaeboe L, Sankila R and Schüz J: Mobile phone use and incidence of glioma in the Nordic countries 1979–2008: Consistency check. Epidemiology. 23:301–307. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Little MP, Rajaraman P, Curtis RE, Devesa SS, Inskip PD, Check DP and Linet MS: Mobile phone use and glioma risk: Comparison of epidemiological study results with incidence trends in the United States. BMJ. 344:e11472012. View Article : Google Scholar : PubMed/NCBI

27 

Zada G, Bond AE, Wang YP, Giannotta SL and Deapen D: Incidence trends in the anatomic location of primary malignant brain tumors in the United States: 1992–2006. World Neurosurg. 77:518–524. 2012. View Article : Google Scholar

28 

Dobes M, Khurana VG, Shadbolt B, Jain S, Smith SF, Smee R, Dexter M and Cook R: Increasing incidence of glioblastoma multiforme and meningioma, and decreasing incidence of Schwannoma (2000–2008): Findings of a multicenter Australian study. Surg Neurol Int. 2:1762011. View Article : Google Scholar

29 

The Danish Cancer Society. The increase in new cases of aggressive brain cancer. http://www.cancer.dk/Nyheder/nyheds-artikler/2012kv4/Kraftigstigningihjernesvulster.htmlurisimplehttp://www.cancer.dk/Nyheder/nyheds-artikler/2012kv4/Kraftigstigningihjernesvulster.html. Accessed September 22, 2014

30 

Schüz J, Jacobsen R, Olsen JH, Boice JD Jr, McLaughlin JK and Johansen C: Cellular telephone use and cancer risk: Update of a nationwide Danish cohort. J Natl Cancer Inst. 98:1707–1713. 2006. View Article : Google Scholar : PubMed/NCBI

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May 2015
Volume 46 Issue 5

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APA
Morgan, L.L., Miller, A.B., Sasco, A., & Davis, D.L. (2015). Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review). International Journal of Oncology, 46, 1865-1871. https://doi.org/10.3892/ijo.2015.2908
MLA
Morgan, L. L., Miller, A. B., Sasco, A., Davis, D. L."Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review)". International Journal of Oncology 46.5 (2015): 1865-1871.
Chicago
Morgan, L. L., Miller, A. B., Sasco, A., Davis, D. L."Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (Review)". International Journal of Oncology 46, no. 5 (2015): 1865-1871. https://doi.org/10.3892/ijo.2015.2908