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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May-2015 Volume 46 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells

  • Authors:
    • Xiangnan Kong
    • Xia Ding
    • Qifeng Yang

  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 2047-2056
    |
    Published online on: March 17, 2015
       https://doi.org/10.3892/ijo.2015.2932
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Abstract

Breast cancer is one of the most common malignant tumors in the world. Long-term maintenance treatment is important for breast cancer. However, effective maintenance treatment is lacking for triple-negative breast cancer (TNBC). Traditional Chinese medicine (TCM) has shown its potential anticancer roles as an effective maintenance treatment for TNBC. However its mechanisms remained unclear. In this study, we detected the differentially expressed genes (DEGs) after treatment with Huaier aqueous extract by using microarray profiling in MDA-MB-231 cells. Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and gene-gene interaction network were conducted to confirm the altered biological functions induced by Huaier extract. Screening of DEGs gave 387 genes (226 upregulated and 161 downregulated) in MDA-MB-231 cells which were regulated significantly by Huaier extract. GO and KEGG pathway analysis suggested that a number of functions were affected by Huaier, including proliferation, apoptosis, migration, and angiogenesis. Gene-gene interaction network showed the detailed molecular signal-net. Based on microarray data, we studied several functions of Huaier extract and in return verified the results of microarray profiling. This study had important guidance roles and indicated new research directions.

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Copy and paste a formatted citation
Spandidos Publications style
Kong X, Ding X and Yang Q: Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells. Int J Oncol 46: 2047-2056, 2015.
APA
Kong, X., Ding, X., & Yang, Q. (2015). Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells. International Journal of Oncology, 46, 2047-2056. https://doi.org/10.3892/ijo.2015.2932
MLA
Kong, X., Ding, X., Yang, Q."Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells". International Journal of Oncology 46.5 (2015): 2047-2056.
Chicago
Kong, X., Ding, X., Yang, Q."Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells". International Journal of Oncology 46, no. 5 (2015): 2047-2056. https://doi.org/10.3892/ijo.2015.2932
Copy and paste a formatted citation
x
Spandidos Publications style
Kong X, Ding X and Yang Q: Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells. Int J Oncol 46: 2047-2056, 2015.
APA
Kong, X., Ding, X., & Yang, Q. (2015). Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells. International Journal of Oncology, 46, 2047-2056. https://doi.org/10.3892/ijo.2015.2932
MLA
Kong, X., Ding, X., Yang, Q."Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells". International Journal of Oncology 46.5 (2015): 2047-2056.
Chicago
Kong, X., Ding, X., Yang, Q."Identification of multi-target effects of Huaier aqueous extract via microarray profiling in triple-negative breast cancer cells". International Journal of Oncology 46, no. 5 (2015): 2047-2056. https://doi.org/10.3892/ijo.2015.2932
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