Open Access

Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells

Retraction in: /10.3892/ijo.2023.5547

  • Authors:
    • Feng Tian
    • Ding Ding
    • Dandan Li
  • View Affiliations

  • Published online on: April 9, 2015     https://doi.org/10.3892/ijo.2015.2959
  • Pages: 2355-2363
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Fangchinoline, an important compound in Stephania tetrandra S. Moore, as a novel antitumor agent, has been implicated in several types of cancers cells except gastric cancer. To investigate whether fangchinoline affects gastric cancer cells, we detected the signaling pathway by which fangchinoline plays a role in different human gastric cancer cells lines. We found that fangchinoline effectively suppressed proliferation and invasion of SGC7901 cell lines, but not MKN45 cell lines by inhibiting the expression of PI3K and its downstream pathway. All of the Akt/MMP2/MMP9 pathway, Akt/Bad pathway, and Akt/Gsk3β/CDK2 pathway could be inhibited by fangchinoline through inhibition of PI3K. Taken together, these results suggest that fangchinoline targets PI3K in tumor cells that express PI3K abundantly and inhibits the growth and invasive ability of the tumor cells.
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June-2015
Volume 46 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tian F, Ding D and Li D: Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells Retraction in /10.3892/ijo.2023.5547. Int J Oncol 46: 2355-2363, 2015.
APA
Tian, F., Ding, D., & Li, D. (2015). Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells Retraction in /10.3892/ijo.2023.5547. International Journal of Oncology, 46, 2355-2363. https://doi.org/10.3892/ijo.2015.2959
MLA
Tian, F., Ding, D., Li, D."Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells Retraction in /10.3892/ijo.2023.5547". International Journal of Oncology 46.6 (2015): 2355-2363.
Chicago
Tian, F., Ding, D., Li, D."Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells Retraction in /10.3892/ijo.2023.5547". International Journal of Oncology 46, no. 6 (2015): 2355-2363. https://doi.org/10.3892/ijo.2015.2959