Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

  • Authors:
    • Nobuhiro Takeno
    • Akiko Inujima
    • Kanna Shinohara
    • Miyuki Yamada
    • Naotoshi Shibahara
    • Hiroaki Sakurai
    • Ikuo Saiki
    • Keiichi Koizumi
  • View Affiliations

  • Published online on: October 15, 2015     https://doi.org/10.3892/ijo.2015.3208
  • Pages: 2115-2122
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Abstract

Japanese traditional herbal medicine (Kampo) have been used to improve the general physical condition after surgery and to mitigate the side effects of radiation and chemotherapy in tumor patients. Juzentaihoto (JTT) consists of ten medical herbs, and is also called Shi-Quan-Da-Bu-Tang in Chinese herbal medicine. Among Kampo medicines, JTT has especially gained attention as a biological response modifier. Currently, clinical trials of various tumor vaccine therapies are being performed world-wide. However, tumor antigens that are inoculated as vaccines do not have high immunogenicity; thus, it is difficult to obtain an effective therapeutic effect. Thus, it is necessary to develop a tumor vaccine adjuvant that is more potent and very safe. In the present study, we examined the efficacy of JTT as an oral adjuvant when given together with tumor vaccines. As a result, JTT enhanced the phagocytic ability of OVA antigen and the presentation ability of OVA antigen in dendritic cells in vitro. Furthermore, tumor growth was markedly decreased, and the survival period was significantly prolonged in mice inoculated with mouse lymphoma, which is expressed with tumor model antigen. In conclusion, these findings suggest that JTT can be used with tumor vaccines as an immune adjuvant.
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December-2015
Volume 47 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Takeno N, Inujima A, Shinohara K, Yamada M, Shibahara N, Sakurai H, Saiki I and Koizumi K: Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model. Int J Oncol 47: 2115-2122, 2015
APA
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H. ... Koizumi, K. (2015). Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model. International Journal of Oncology, 47, 2115-2122. https://doi.org/10.3892/ijo.2015.3208
MLA
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H., Saiki, I., Koizumi, K."Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model". International Journal of Oncology 47.6 (2015): 2115-2122.
Chicago
Takeno, N., Inujima, A., Shinohara, K., Yamada, M., Shibahara, N., Sakurai, H., Saiki, I., Koizumi, K."Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model". International Journal of Oncology 47, no. 6 (2015): 2115-2122. https://doi.org/10.3892/ijo.2015.3208