Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer

Thang,Phung Manh; Takano,Atsushi; Yoshitake,Yoshihiro; Shinohara,Masanori; Murakami,Yoshinori; Daigo,Yataro

doi:10.3892/ijo.2016.3649

Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer

Authors:
- Phung Manh Thang
- Atsushi Takano
- Yoshihiro Yoshitake
- Masanori Shinohara
- Yoshinori Murakami
- Yataro Daigo
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Affiliations: Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Department of Oral and Maxillofacial Surgery, Kumamoto University, Kumamoto, Japan, Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Published online on: August 5, 2016 https://doi.org/10.3892/ijo.2016.3649
Pages: 1385-1393

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Abstract

Oral cavity carcinoma (OCC) is one of the most common causes of cancer-related death worldwide and has poor clinical outcome after standard therapies. Therefore, new prognostic biomarkers and therapeutic targets for OCC are urgently needed. We selected cell division cycle associated 1 (CDCA1) as a candidate OCC biomarker. Immunohistochemical analysis confirmed that CDCA1 protein was expressed in 67 of 99 OCC tissues (67.7%), but not in healthy oral epithelia. CDCA1 expression was significantly associated with poor prognosis in OCC patients (P=0.0244). Knockdown of CDCA1 by siRNAs significantly increased apoptosis of tumor cells. These data suggest that CDCA1 represents a novel prognostic biomarker and therapeutic target for OCC.

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