Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells

  • Authors:
    • Shinji Mikami
    • Ichiro Ota
    • Takashi Masui
    • Asako Itaya‑Hironaka
    • Ryogo Shobatake
    • Hideyuki Okamoto
    • Shin Takasawa
    • Tadashi Kitahara
  • View Affiliations

  • Published online on: August 19, 2016     https://doi.org/10.3892/ijo.2016.3664
  • Pages: 1553-1560
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Abstract

Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.
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October-2016
Volume 49 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mikami S, Ota I, Masui T, Itaya‑Hironaka A, Shobatake R, Okamoto H, Takasawa S and Kitahara T: Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. Int J Oncol 49: 1553-1560, 2016
APA
Mikami, S., Ota, I., Masui, T., Itaya‑Hironaka, A., Shobatake, R., Okamoto, H. ... Kitahara, T. (2016). Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells. International Journal of Oncology, 49, 1553-1560. https://doi.org/10.3892/ijo.2016.3664
MLA
Mikami, S., Ota, I., Masui, T., Itaya‑Hironaka, A., Shobatake, R., Okamoto, H., Takasawa, S., Kitahara, T."Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells". International Journal of Oncology 49.4 (2016): 1553-1560.
Chicago
Mikami, S., Ota, I., Masui, T., Itaya‑Hironaka, A., Shobatake, R., Okamoto, H., Takasawa, S., Kitahara, T."Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells". International Journal of Oncology 49, no. 4 (2016): 1553-1560. https://doi.org/10.3892/ijo.2016.3664