REVERSION OF RESISTANCE TO ADRIAMYCIN BY VANADATE ON 4 FRIEND-CELL SUBLINES

  • Authors:
    • B DESOIZE
    • F BRIOIS
    • Y CARPENTIER
  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/ijo.5.1.87
  • Pages: 87-91
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The retention of adriamycin in 5 Friend cell sublines of increasing degree of resistance was enhanced in vitro by three compounds: verapamil, nigericine and vanadate. Vanadate had the strongest activity, it enhanced also the incorporation in sensitive cells. Its efficacy was increased by a pre-incubation with H2O2. The effect of vanadate was then tested in vivo. When the tumor was transplanted i.p. and the treatment was also i.p., vanadate enhanced the efficacy of adriamycin, but it had also an antitumor activity by itself. Vanadate alone had some efficacy on the Friend cells of the lowest degree of resistance, when adriamycin had no effect. Nevertheless, vanadate had a partial cross resistance with adriamycin on these cells. When the tumor was transplanted subcutaneously and the treatment was still i.p., vanadate had no effect whilst adriamycin was still active.

Related Articles

Journal Cover

July 1994
Volume 5 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
DESOIZE B, BRIOIS F and CARPENTIER Y: REVERSION OF RESISTANCE TO ADRIAMYCIN BY VANADATE ON 4 FRIEND-CELL SUBLINES. Int J Oncol 5: 87-91, 1994
APA
DESOIZE, B., BRIOIS, F., & CARPENTIER, Y. (1994). REVERSION OF RESISTANCE TO ADRIAMYCIN BY VANADATE ON 4 FRIEND-CELL SUBLINES. International Journal of Oncology, 5, 87-91. https://doi.org/10.3892/ijo.5.1.87
MLA
DESOIZE, B., BRIOIS, F., CARPENTIER, Y."REVERSION OF RESISTANCE TO ADRIAMYCIN BY VANADATE ON 4 FRIEND-CELL SUBLINES". International Journal of Oncology 5.1 (1994): 87-91.
Chicago
DESOIZE, B., BRIOIS, F., CARPENTIER, Y."REVERSION OF RESISTANCE TO ADRIAMYCIN BY VANADATE ON 4 FRIEND-CELL SUBLINES". International Journal of Oncology 5, no. 1 (1994): 87-91. https://doi.org/10.3892/ijo.5.1.87