EXPRESSION OF INTERLEUKIN-6 IN TUMOR-BEARING MICE WITH CYTOKINE DEPENDENT CACHEXIA

  • Authors:
    • C LONNROTH
    • J GELIN
    • K LUNDHOLM
  • View Affiliations

  • Published online on: August 1, 1994     https://doi.org/10.3892/ijo.5.2.329
  • Pages: 329-336
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Abstract

Increased production of IL-6 in tumor-bearing mice occured in a variety of host-tissues including tumor tissue. Elevated IL-6 transcription in tumor-bearing mice occured in the tumor, liver, kidney and the small intestine, and was associated with increased concentration in the circulation of bioactive IL-6 of normal size (almost-equal-to 20 000 kDa) in addition with two larger but biologically inactive serum fractions containing immune-reactive IL-6. These inactive complexes were not explained by circulating inhibitor(s). The occurrence of differently sized tumor and host-tissue IL-6 mRNAs were dependent on the subcellular location (nuclear, ribosomal, cytoplasm). the tissue type and the kind of cellular stimulation. In tumor-tissue, IL-6 was produced to the highest concentration in tumor cells, followed by inflammatory and endothelial cells respectively, but IL-6 did not seem to represent an autocrine growth factor loop as earlier reported by us for both IL-1alpha and TNFalpha in the present tumor model. In contrast, evidence supported that IL-6 acted as a paracrinic factor in this model stimulated by some other host-derived factor(s).

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August 1994
Volume 5 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
LONNROTH C, GELIN J and LUNDHOLM K: EXPRESSION OF INTERLEUKIN-6 IN TUMOR-BEARING MICE WITH CYTOKINE DEPENDENT CACHEXIA. Int J Oncol 5: 329-336, 1994
APA
LONNROTH, C., GELIN, J., & LUNDHOLM, K. (1994). EXPRESSION OF INTERLEUKIN-6 IN TUMOR-BEARING MICE WITH CYTOKINE DEPENDENT CACHEXIA. International Journal of Oncology, 5, 329-336. https://doi.org/10.3892/ijo.5.2.329
MLA
LONNROTH, C., GELIN, J., LUNDHOLM, K."EXPRESSION OF INTERLEUKIN-6 IN TUMOR-BEARING MICE WITH CYTOKINE DEPENDENT CACHEXIA". International Journal of Oncology 5.2 (1994): 329-336.
Chicago
LONNROTH, C., GELIN, J., LUNDHOLM, K."EXPRESSION OF INTERLEUKIN-6 IN TUMOR-BEARING MICE WITH CYTOKINE DEPENDENT CACHEXIA". International Journal of Oncology 5, no. 2 (1994): 329-336. https://doi.org/10.3892/ijo.5.2.329