MONOCLONAL-ANTIBODIES TO HUMAN BREAST-CANCER ASSOCIATED ANTIGENS

  • Authors:
    • AK GUHA
    • T GHOSE
    • SJ LUNER
    • H NOLIDO-CRUZ
    • M MAMMEN
    • SE ILES
    • G FAULKNER
    • JA AQUINO
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1385
  • Pages: 1385-1398
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Abstract

Eleven murine monoclonal antibodies (MABs) were produced using human mammary cancer (HMC) cell lines as immunogens: None reacted with normal breast tissue, but each had a distinctive pattern of reactivity with HMC and benign proliferative lesions. Two MABs bound to overlapping epitopes of an M(r) 47,000 cell-surface antigen and were endocytosed: nine bound to secretable intracytoplasmic antigens(s). Four of the MABs immunoprecipitate antigens that upon reduction yielded an M(r) 73,000 moiety. None reacted with components of milk. All antigens were sensitive to trypsin, three to periodate oxidation but none to neuraminidase. One cell-surface-localizing MAB investigated, selectively localized in HMC xenografts.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
GUHA A, GHOSE T, LUNER S, NOLIDO-CRUZ H, MAMMEN M, ILES S, FAULKNER G and AQUINO J: MONOCLONAL-ANTIBODIES TO HUMAN BREAST-CANCER ASSOCIATED ANTIGENS. Int J Oncol 5: 1385-1398, 1994.
APA
GUHA, A., GHOSE, T., LUNER, S., NOLIDO-CRUZ, H., MAMMEN, M., ILES, S. ... AQUINO, J. (1994). MONOCLONAL-ANTIBODIES TO HUMAN BREAST-CANCER ASSOCIATED ANTIGENS. International Journal of Oncology, 5, 1385-1398. https://doi.org/10.3892/ijo.5.6.1385
MLA
GUHA, A., GHOSE, T., LUNER, S., NOLIDO-CRUZ, H., MAMMEN, M., ILES, S., FAULKNER, G., AQUINO, J."MONOCLONAL-ANTIBODIES TO HUMAN BREAST-CANCER ASSOCIATED ANTIGENS". International Journal of Oncology 5.6 (1994): 1385-1398.
Chicago
GUHA, A., GHOSE, T., LUNER, S., NOLIDO-CRUZ, H., MAMMEN, M., ILES, S., FAULKNER, G., AQUINO, J."MONOCLONAL-ANTIBODIES TO HUMAN BREAST-CANCER ASSOCIATED ANTIGENS". International Journal of Oncology 5, no. 6 (1994): 1385-1398. https://doi.org/10.3892/ijo.5.6.1385