CLINICAL AND IMMUNOLOGICAL EFFECTS OF A SYNTHETIC BETA-HUMAN CHORIONIC-GONADOTROPIN VACCINE

  • Authors:
    • PL TRIOZZI
    • D GOCHNOUR
    • EW MARTIN
    • W ALDRICH
    • J POWELL
    • JA KIM
    • DC YOUNG
    • J LOMBARDI
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1447
  • Pages: 1447-1453
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Abstract

We treated 23 patients with non-trophoblastic cancers with escalating doses of a synthetic vaccine consisting of the carboxy-terminal peptide of beta human chorionic gonadotropin conjugated to diphtheria toroid (CTP37), a muramyl dipeptide as an adjuvant, and squalene/mannide monooleate as a vehicle. Toxicity consisted of pain and sterile abscess formation at the injection site and of constitutional symptoms. Diphtheria toxoid hypersensitivity developed in one patient. Immunizations elicited anti-beta hCG IgG antibody which persisted for more than 10 months. Disappearance of circulating hCG present pre-immunization and tumor regressions were observed. Active specific immunotherapy with CTP37 vaccine is well-tolerated and has biological activity in patients with cancer.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TRIOZZI P, GOCHNOUR D, MARTIN E, ALDRICH W, POWELL J, KIM J, YOUNG D and LOMBARDI J: CLINICAL AND IMMUNOLOGICAL EFFECTS OF A SYNTHETIC BETA-HUMAN CHORIONIC-GONADOTROPIN VACCINE. Int J Oncol 5: 1447-1453, 1994.
APA
TRIOZZI, P., GOCHNOUR, D., MARTIN, E., ALDRICH, W., POWELL, J., KIM, J. ... LOMBARDI, J. (1994). CLINICAL AND IMMUNOLOGICAL EFFECTS OF A SYNTHETIC BETA-HUMAN CHORIONIC-GONADOTROPIN VACCINE. International Journal of Oncology, 5, 1447-1453. https://doi.org/10.3892/ijo.5.6.1447
MLA
TRIOZZI, P., GOCHNOUR, D., MARTIN, E., ALDRICH, W., POWELL, J., KIM, J., YOUNG, D., LOMBARDI, J."CLINICAL AND IMMUNOLOGICAL EFFECTS OF A SYNTHETIC BETA-HUMAN CHORIONIC-GONADOTROPIN VACCINE". International Journal of Oncology 5.6 (1994): 1447-1453.
Chicago
TRIOZZI, P., GOCHNOUR, D., MARTIN, E., ALDRICH, W., POWELL, J., KIM, J., YOUNG, D., LOMBARDI, J."CLINICAL AND IMMUNOLOGICAL EFFECTS OF A SYNTHETIC BETA-HUMAN CHORIONIC-GONADOTROPIN VACCINE". International Journal of Oncology 5, no. 6 (1994): 1447-1453. https://doi.org/10.3892/ijo.5.6.1447