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EXPRESSION OF NM23-H1 GENE IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX CORRELATES WITH 5-YEAR SURVIVAL

  • Authors:
    • M ILIJAS
    • K PAVELIC
    • B SARCEVIC
    • S KAPITANOVIC
    • A KURJAK
    • PJ STAMBROOK
    • JL GLUCKMAN
    • ZP PAVELIC

  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1455
  • Pages: 1455-1457
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Abstract

We have examined nm23-H1 protein levels in human squamous cell carcinoma of the cervix by immunohistochemistry and correlated detectable nm23-H1 with patient survival. Normal cervical tissue samples were consistently strongly immunoreactive. In contrast, cervical carcinomas stained poorly, if at all. Well differentiated carcinomas stained more frequently for nm23-H1 protein than poorly or undifferentiated carcinomas. Our results clearly demonstrated a significant correlation between absence of nm23-H1 protein staining and shorter survival of patients with cervical cancer. Our results suggest that nm23 may serve as a potentially valuable prognostic marker for this type of tumor and to our knowledge is the first report of this kind for cervical carcinoma.

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December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 5.2
  • Ranked Oncology
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  • CiteScore: 11.4
  • CiteScore Rank: Q1: #40/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 1.125
  • SCImago Journal Rank (SJR): 1.105
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Spandidos Publications style
ILIJAS M, PAVELIC K, SARCEVIC B, KAPITANOVIC S, KURJAK A, STAMBROOK P, GLUCKMAN J and PAVELIC Z: EXPRESSION OF NM23-H1 GENE IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX CORRELATES WITH 5-YEAR SURVIVAL. Int J Oncol 5: 1455-1457, 1994
APA
ILIJAS, M., PAVELIC, K., SARCEVIC, B., KAPITANOVIC, S., KURJAK, A., STAMBROOK, P. ... PAVELIC, Z. (1994). EXPRESSION OF NM23-H1 GENE IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX CORRELATES WITH 5-YEAR SURVIVAL. International Journal of Oncology, 5, 1455-1457. https://doi.org/10.3892/ijo.5.6.1455
MLA
ILIJAS, M., PAVELIC, K., SARCEVIC, B., KAPITANOVIC, S., KURJAK, A., STAMBROOK, P., GLUCKMAN, J., PAVELIC, Z."EXPRESSION OF NM23-H1 GENE IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX CORRELATES WITH 5-YEAR SURVIVAL". International Journal of Oncology 5.6 (1994): 1455-1457.
Chicago
ILIJAS, M., PAVELIC, K., SARCEVIC, B., KAPITANOVIC, S., KURJAK, A., STAMBROOK, P., GLUCKMAN, J., PAVELIC, Z."EXPRESSION OF NM23-H1 GENE IN SQUAMOUS-CELL CARCINOMA OF THE CERVIX CORRELATES WITH 5-YEAR SURVIVAL". International Journal of Oncology 5, no. 6 (1994): 1455-1457. https://doi.org/10.3892/ijo.5.6.1455