S100B expression in breast cancer as a predictive marker for cancer metastasis

  • Authors:
    • Meng-Chi Yen
    • Yung-Chi Huang
    • Jung-Yu Kan
    • Po-Lin Kuo
    • Ming-Feng Hou
    • Ya-Ling Hsu
  • View Affiliations

  • Published online on: December 12, 2017     https://doi.org/10.3892/ijo.2017.4226
  • Pages: 433-440
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Abstract

In the tumor microenvironment, soluble molecules play important role in the establishment of a pre-metastatic niche. The S100 calcium-binding protein family are inflammatory molecules that contribute to the development of a pro-inflammatory tumor microenvironment. S100B belongs to the S100 family and serum S100B (also known as S100beta) serves as a marker for metastasis in lung cancer, ovarian cancer and melanoma. However, the association between S100B and the metastasis of breast cancer is not yet well understood. In the present study, a relatively low S100B expression was observed in the tumor samples compared to normal breast tissue among online microarray datasets. When the estrogen receptor (ER)-negative breast cancer cell lines, MDA-MB-231 and Hs578T, were treated with recombinant human S100B, cell migration was significantly inhibited and epithelial cadherin expression was increased. Our results revealed that a high S100B expression predicted a good overall survival in patients with ER-negative breast cancer, and good distant metastases-free survival in all patients with breast cancer via the analysis of the KM plotter and SurvExpress databases. Although previous studies have indicated that the interaction of S100B with wild-type p53 inhibits p53 function, a high S100B expression is associated with a good prognosis in patients with p53 mutant and p53 wild-type breast cancers. On the whole, our findings demonstrate that S100B treatment suppresses the migratory capacity of ER-negative breast cancer and that S100B expression may serve a predictive marker for metastasis in breast cancer.

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February 2018
Volume 52 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Yen, M., Huang, Y., Kan, J., Kuo, P., Hou, M., & Hsu, Y. (2018). S100B expression in breast cancer as a predictive marker for cancer metastasis. International Journal of Oncology, 52, 433-440. https://doi.org/10.3892/ijo.2017.4226
MLA
Yen, M., Huang, Y., Kan, J., Kuo, P., Hou, M., Hsu, Y."S100B expression in breast cancer as a predictive marker for cancer metastasis". International Journal of Oncology 52.2 (2018): 433-440.
Chicago
Yen, M., Huang, Y., Kan, J., Kuo, P., Hou, M., Hsu, Y."S100B expression in breast cancer as a predictive marker for cancer metastasis". International Journal of Oncology 52, no. 2 (2018): 433-440. https://doi.org/10.3892/ijo.2017.4226