|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Poruk KE, Firpo MA, Adler DG and Mulvihill
SJ: Screening for pancreatic cancer: Why, how, and who? Ann Surg.
257:17–26. 2013. View Article : Google Scholar
|
|
3
|
Ryan DP, Hong TS and Bardeesy N:
Pancreatic adenocarcinoma. N Engl J Med. 371:1039–1049. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Uesaka K, Boku N, Fukutomi A, Okamura Y,
Konishi M, Matsumoto I, Kaneoka Y, Shimizu Y, Nakamori S, Sakamoto
H, et al JASPAC 01 Study Group: Adjuvant chemotherapy of S-1 versus
gemcitabine for resected pancreatic cancer: A phase 3, open-label,
randomised, non-inferiority trial (JASPAC 01). Lancet. 388:248–257.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Xiong XD, Ren X, Cai MY, Yang JW, Liu X
and Yang JM: Long non-coding RNAs: An emerging powerhouse in the
battle between life and death of tumor cells. Drug Resist Updat.
26:28–42. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Qi P and Du X: The long non-coding RNAs, a
new cancer diagnostic and therapeutic gold mine. Mod Pathol.
26:155–165. 2013. View Article : Google Scholar
|
|
7
|
Xie Z, Chen X, Li J, Guo Y, Li H, Pan X,
Jiang J, Liu H and Wu B: Salivary HOTAIR and PVT1 as novel
biomarkers for early pancreatic cancer. Oncotarget. 7:25408–25419.
2016.PubMed/NCBI
|
|
8
|
Zheng S, Chen H, Wang Y, Gao W, Fu Z, Zhou
Q, Jiang Y, Lin Q, Tan L, Ye H, et al: Long non-coding RNA
LOC389641 promotes progression of pancreatic ductal adenocarcinoma
and increases cell invasion by regulating E-cadherin in a
TNFRSF10A-related manner. Cancer Lett. 371:354–365. 2016.
View Article : Google Scholar
|
|
9
|
Li X, Deng SJ, Zhu S, Jin Y, Cui SP, Chen
JY, Xiang C, Li QY, He C, Zhao SF, et al: Hypoxia-induced
lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic
cancer by derepressing the miR-3923/KRAS pathway. Oncotarget.
7:6000–6014. 2016.PubMed/NCBI
|
|
10
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
11
|
Zhang X, Sun S, Pu JK, Tsang AC, Lee D,
Man VO, Lui WM, Wong ST and Leung GK: Long non-coding RNA
expression profiles predict clinical phenotypes in glioma.
Neurobiol Dis. 48:1–8. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Harrow J, Denoeud F, Frankish A, Reymond
A, Chen CK, Chrast J, Lagarde J, Gilbert JG, Storey R, Swarbreck D,
et al: GENCODE: producing a reference annotation for ENCODE. Genome
Biol. 7(Suppl 1): S41–9. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ørom UA, Derrien T, Beringer M, Gumireddy
K, Gardini A, Bussotti G, Lai F, Zytnicki M, Notredame C, Huang Q,
et al: Long noncoding RNAs with enhancer-like function in human
cells. Cell. 143:46–58. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Guttman M, Amit I, Garber M, French C, Lin
MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, et al:
Chromatin signature reveals over a thousand highly conserved large
non-coding RNAs in mammals. Nature. 458:223–227. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Miyake T, Honma Y, Urano T, Kato N and
Suzumiya J: Combined treatment with tamoxifen and a fusicoccin
derivative (ISIR-042) to overcome resistance to therapy and to
enhance the antitumor activity of 5-fluorouracil and gemcitabine in
pancreatic cancer cells. Int J Oncol. 47:315–324. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wang Y, Chen W, Yang C, Wu W, Wu S, Qin X
and Li X: Long non-coding RNA UCA1a(CUDR) promotes proliferation
and tumorigenesis of bladder cancer. Int J Oncol. 41:276–284.
2012.PubMed/NCBI
|
|
17
|
Tsang WP, Wong TWL, Cheung AHH, Co CNN and
Kwok TT: Induction of drug resistance and transformation in human
cancer cells by the noncoding RNA CUDR. RNA. 13:890–898. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu
M and Mo YY: Long non-coding RNA UCA1 promotes breast tumor growth
by suppression of p27 (Kip1). Cell Death Dis. 5:e10082014.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Pu H, Zheng Q, Li H, Wu M, An J, Gui X, Li
T and Lu D: CUDR promotes liver cancer stem cell growth through
upregulating TERT and C-Myc. Oncotarget. 6:40775–40798. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Han Y, Yang YN, Yuan HH, Zhang TT, Sui H,
Wei XL, Liu L, Huang P, Zhang WJ and Bai YX: UCA1, a long
non-coding RNA up-regulated in colorectal cancer influences cell
proliferation, apoptosis and cell cycle distribution. Pathology.
46:396–401. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Zheng Q, Wu F, Dai WY, Zheng DC, Zheng C,
Ye H, Zhou B, Chen JJ and Chen P: Aberrant expression of UCA1 in
gastric cancer and its clinical significance. Clin Transl Oncol.
17:640–646. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Fang Z, Wu L, Wang L, Yang Y, Meng Y and
Yang H: Increased expression of the long non-coding RNA UCA1 in
tongue squamous cell carcinomas: A possible correlation with cancer
metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol. 117:89–95.
2014. View Article : Google Scholar
|
|
23
|
Chen P, Wan D, Zheng D, Zheng Q, Wu F and
Zhi Q: Long non-coding RNA UCA1 promotes the tumorigenesis in
pancreatic cancer. Biomed Pharmacother. 83:1220–1226. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Fu XL, Liu DJ, Yan TT, Yang JY, Yang MW,
Li J, Huo YM, Liu W, Zhang JF, Hong J, et al: Analysis of long
non-coding RNA expression profiles in pancreatic ductal
adenocarcinoma. Sci Rep. 6:335352016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhang X, Gao F, Zhou L, Wang H, Shi G and
Tan X: UCA1 regulates the growth and metastasis of pancreatic
cancer by sponging miR-135a. Oncol Res. 25:1529–1541. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Cheng N, Cai W, Ren S, Li X, Wang Q, Pan
H, Zhao M, Li J, Zhang Y, Zhao C, et al: Long non-coding RNA UCA1
induces non-T790M acquired resistance to EGFR-TKIs by activating
the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer.
Oncotarget. 6:23582–23593. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Wang ZQ, Cai Q, Hu L, He CY, Li JF, Quan
ZW, Liu BY, Li C and Zhu ZG: Long noncoding RNA UCA1 induced by SP1
promotes cell proliferation via recruiting EZH2 and activating AKT
pathway in gastric cancer. Cell Death Dis. 8:e28392017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Pan JJ and Yang MH: The role of
epithelial-mesenchymal transition in pancreatic cancer. J
Gastrointest Oncol. 2:151–156. 2011.
|
|
29
|
Zhan HX, Wang Y, Li C, Xu JW, Zhou B, Zhu
JK, Han HF, Wang L, Wang YS and Hu SY: LincRNA-ROR promotes
invasion, metastasis and tumor growth in pancreatic cancer through
activating ZEB1 pathway. Cancer Lett. 374:261–271. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Jiao F, Hu H, Yuan C and Wang L, Jiang W,
Jin Z, Guo Z and Wang L: Elevated expression level of long
noncoding RNA MALAT-1 facilitates cell growth, migration and
invasion in pancreatic cancer. Oncol Rep. 32:2485–2492. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Ma L, Wang F, Du C, Zhang Z, Guo H, Xie X,
Gao H, Zhuang Y, Kornmann M, Gao H, et al: Long non-coding RNA MEG3
functions as a tumour suppressor and has prognostic predictive
value in human pancreatic cancer. Oncol Rep. 39:1132–1140.
2018.PubMed/NCBI
|
|
32
|
Ren Y, Jia HH, Xu YQ, Zhou X, Zhao XH,
Wang YF, Song X, Zhu ZY, Sun T, Dou Y, et al: Paracrine and
epigenetic control of CAF-induced metastasis: The role of HOTAIR
stimulated by TGF-ß1 secretion. Mol Cancer. 17:52018. View Article : Google Scholar
|
|
33
|
Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan
Z and Ai K: H19 promotes pancreatic cancer metastasis by
derepressing let-7’s suppression on its target HMGA2-mediated EMT.
Tumour Biol. 35:9163–9169. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Taube JH, Herschkowitz JI, Komurov K, Zhou
AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, et
al: Core epithelial-to-mesenchymal transition interactome
gene-expression signature is associated with claudin-low and
metaplastic breast cancer subtypes. Proc Natl Acad Sci USA.
107:15449–15454. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Thamilselvan V, Craig DH and Basson MD:
FAK association with multiple signal proteins mediates
pressure-induced colon cancer cell adhesion via a Src-dependent
PI3K/Akt pathway. FASEB J. 21:1730–1741. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Miyazaki T, Karube M, Matsuzaki Y, Ikegami
T, Doy M, Tanaka N and Bouscarel B: Taurine inhibits oxidative
damage and prevents fibrosis in carbon tetrachloride-induced
hepatic fibrosis. J Hepatol. 43:117–125. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Itoh N, Semba S, Ito M, Takeda H, Kawata S
and Yamakawa M: Phosphorylation of Akt/PKB is required for
suppression of cancer cell apoptosis and tumor progression in human
colorectal carcinoma. Cancer. 94:3127–3134. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Tanno S, Tanno S, Mitsuuchi Y, Altomare
DA, Xiao GH and Testa JR: AKT activation up-regulates insulin-like
growth factor I receptor expression and promotes invasiveness of
human pancreatic cancer cells. Cancer Res. 61:589–593.
2001.PubMed/NCBI
|
|
39
|
Tao C, Lin H and Chen S: The regulation of
ERK and p-ERK expression by cisplatin and sorafenib in gastric
cancer cells. Gene. 552:106–115. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Ohtsuka S, Ogawa S, Wakamatsu E and Abe R:
Cell cycle arrest caused by MEK/ERK signaling is a mechanism for
suppressing growth of antigen-hyperstimulated effector T cells. Int
Immunol. 28:547–557. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Deer EL, González-Hernández J, Coursen JD,
Shea JE, Ngatia J, Scaife CL, Firpo MA and Mulvihill SJ: Phenotype
and genotype of pancreatic cancer cell lines. Pancreas. 39:425–435.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Mann KM, Ying H, Juan J, Jenkins NA and
Copeland NG: KRAS-related proteins in pancreatic cancer. Pharmacol
Ther. 168:29–42. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Larue L and Bellacosa A:
Epithelial-mesenchymal transition in development and cancer: Role
of phosphatidylinositol 3′ kinase/ AKT pathways. Oncogene.
24:7443–7454. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Liu A, Shao C, Jin G, Liu R, Hao J, Song
B, Ouyang L and Hu X: miR-208-induced epithelial to mesenchymal
transition of pancreatic cancer cells promotes cell metastasis and
invasion. Cell Biochem Biophys. 69:341–346. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Tashiro E, Henmi S, Odake H, Ino S and
Imoto M: Involvement of the MEK/ERK pathway in EGF-induced
E-cadherin down-regulation. Biochem Biophys Res Commun.
477:801–806. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Iser IC, Pereira MB, Lenz G and Wink MR:
The epithelial-to-mesenchymal transition-like process in
glioblastoma: An updated systematic review and in silico
investigation. Med Res Rev. 37:271–313. 2017. View Article : Google Scholar
|
|
47
|
Zheng X, Carstens JL, Kim J, Scheible M,
Kaye J, Sugimoto H, Wu CC, LeBleu VS and Kalluri R:
Epithelial-to-mesenchymal transition is dispensable for metastasis
but induces chemoresistance in pancreatic cancer. Nature.
527:525–530. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Arumugam T, Ramachandran V, Fournier KF,
Wang H, Marquis L, Abbruzzese JL, Gallick GE, Logsdon CD, McConkey
DJ and Choi W: Epithelial to mesenchymal transition contributes to
drug resistance in pancreatic cancer. Cancer Res. 69:5820–5828.
2009. View Article : Google Scholar : PubMed/NCBI
|
