PREVALENCE OF C-ERBB3 EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE CERVIX AS DETERMINED BY THE MONOCLONAL-ANTIBODY RTJ2

  • Authors:
    • T RAJKUMAR
    • U MAJHI
    • V MALLIGARJUNA
    • WJ GULLICK
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.105
  • Pages: 105-109
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Abstract

The c-erbB3 protein is a member of the type 1 tyrosine kinase growth factor receptor family. We report on the production and characterisation of a monoclonal antibody, RTJ2, raised against a synthetic peptide from the cytoplasmic domain of the molecule. The antibody is specific for c-erbB3 protein as determined by Western blotting, immunoprecipitation and immunocytochemistry. Using this monoclonal antibody we have evaluated the prevalence of expression of the c-erbB3 protein in 72 squamous cell carcinomas of the cervix. 17 of the 72 (23.6%) tumours were found to overexpress c-erbB3 protein relative to the levels seen in the normal epithelium. Overexpression was not correlated with stage, grade or histologic subtype of the tumours. The high incidence of c-erbB3 overexpression relative to the normal tissue suggests a possible role for c-erbB3 in the oncogenesis of cervical epithelium.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RAJKUMAR T, MAJHI U, MALLIGARJUNA V and GULLICK W: PREVALENCE OF C-ERBB3 EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE CERVIX AS DETERMINED BY THE MONOCLONAL-ANTIBODY RTJ2. Int J Oncol 6: 105-109, 1995.
APA
RAJKUMAR, T., MAJHI, U., MALLIGARJUNA, V., & GULLICK, W. (1995). PREVALENCE OF C-ERBB3 EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE CERVIX AS DETERMINED BY THE MONOCLONAL-ANTIBODY RTJ2. International Journal of Oncology, 6, 105-109. https://doi.org/10.3892/ijo.6.1.105
MLA
RAJKUMAR, T., MAJHI, U., MALLIGARJUNA, V., GULLICK, W."PREVALENCE OF C-ERBB3 EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE CERVIX AS DETERMINED BY THE MONOCLONAL-ANTIBODY RTJ2". International Journal of Oncology 6.1 (1995): 105-109.
Chicago
RAJKUMAR, T., MAJHI, U., MALLIGARJUNA, V., GULLICK, W."PREVALENCE OF C-ERBB3 EXPRESSION IN SQUAMOUS-CELL CARCINOMAS OF THE CERVIX AS DETERMINED BY THE MONOCLONAL-ANTIBODY RTJ2". International Journal of Oncology 6, no. 1 (1995): 105-109. https://doi.org/10.3892/ijo.6.1.105