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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 1995 Volume 6 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 1995 Volume 6 Issue 2

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Article

A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER

  • Authors:
    • JP SCULIER
    • J THIRIAUX
    • G BUREAU
    • JJ LAFITTE
    • P RECLOUX
    • D BROHEE
    • MC BERCHIER
    • R SERGYSELS
    • P MOMMEN
    • M PAESMANS
    • J KLASTERSKY
    • J LECOMTE
    • C VANSCHAARDENBURG
    • V RICHARD
    • D DIANA
    • F FORTIN
    • A TAGNON
    • U KUSTNER
  • View Affiliations / Copyright

    Affiliations: HOP CIVIL CHARLEROI,CHARLEROI,BELGIUM. GRP MED ST REMI,REIMS,FRANCE. HOP A CALMETTE,LILLE,FRANCE. HOP AMBROISE PARE,MONS,BELGIUM. CHU ANDRE VESALE,MONTIGNIES TILLEUL,BELGIUM. HOP HAYANGE,HAYANGE,FRANCE. ACAD ZIEKENHUIS MIDDELHEIM,ANTWERP,BELGIUM. CLIN LOUIS CATY,BAUDOUR,BELGIUM. CLIN LOUVIERE,LILLE,FRANCE. IMC MUTUALIT SOCIALISTES,TOURNAI,BELGIUM. LUNGENKLIN HECKESHORN,BERLIN,GERMANY.
  • Pages: 425-429
    |
    Published online on: February 1, 1995
       https://doi.org/10.3892/ijo.6.2.425
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Abstract

A phase II trial was conducted to determine the effectiveness of weekly administration of cisplatin (25 mg/m(2) on day 1) and carboplatin (100 mg/m(2) on day 1) as salvage chemotherapy for patients with small cell lung cancer after first-line chemotherapy without platinum derivatives. Of 40 eligible patients, 38 were evaluable for response. Interval between last course of first-line chemotherapy and first course of salvage therapy was less than 3 months in 34 and greater in 4. Five partial responses (13%; confidence interval at 95%:0.01-0.25) were documented (including 4 in patients with a treatment-free interval <3 months) as well as 8 no change, 21 progressions and 4 early deaths due to malignant disease. Toxicity consisted mainly of moderate thrombopenia and leucopenia. Grade I nephrotoxicity was observed in 6 patients. In conclusion, weekly administration of moderate doses of cisplatin and carboplatin as salvage chemotherapy for small cell lung cancer appeared feasible and was associated with a moderate but definitive anticancer activity.

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Copy and paste a formatted citation
Spandidos Publications style
SCULIER J, THIRIAUX J, BUREAU G, LAFITTE J, RECLOUX P, BROHEE D, BERCHIER M, SERGYSELS R, MOMMEN P, PAESMANS M, PAESMANS M, et al: A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER. Int J Oncol 6: 425-429, 1995.
APA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D. ... KUSTNER, U. (1995). A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER. International Journal of Oncology, 6, 425-429. https://doi.org/10.3892/ijo.6.2.425
MLA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6.2 (1995): 425-429.
Chicago
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6, no. 2 (1995): 425-429. https://doi.org/10.3892/ijo.6.2.425
Copy and paste a formatted citation
x
Spandidos Publications style
SCULIER J, THIRIAUX J, BUREAU G, LAFITTE J, RECLOUX P, BROHEE D, BERCHIER M, SERGYSELS R, MOMMEN P, PAESMANS M, PAESMANS M, et al: A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER. Int J Oncol 6: 425-429, 1995.
APA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D. ... KUSTNER, U. (1995). A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER. International Journal of Oncology, 6, 425-429. https://doi.org/10.3892/ijo.6.2.425
MLA
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6.2 (1995): 425-429.
Chicago
SCULIER, J., THIRIAUX, J., BUREAU, G., LAFITTE, J., RECLOUX, P., BROHEE, D., BERCHIER, M., SERGYSELS, R., MOMMEN, P., PAESMANS, M., KLASTERSKY, J., LECOMTE, J., VANSCHAARDENBURG, C., RICHARD, V., DIANA, D., FORTIN, F., TAGNON, A., KUSTNER, U."A PHASE-II STUDY TESTING WEEKLY PLATINUM DERIVATIVE COMBINATION CHEMOTHERAPY AS 2ND-LINE TREATMENT IN PATIENTS WITH ADVANCED SMALL-CELL LUNG-CANCER". International Journal of Oncology 6, no. 2 (1995): 425-429. https://doi.org/10.3892/ijo.6.2.425
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